Data Sheet 3_Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enable RNA virus discovery.fasta
<p>The functions of RNA-dependent RNA polymerases (RdRps) in RNA viruses are demonstrably modulated by native substrates of dynamic and interconvertible conformational ensembles. Many of these are populated by essential flexible or intrinsically disordered regions (IDRs) that lack a stable thr...
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2025
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