Data Sheet 3_Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enable RNA virus discovery.fasta

Data Sheet 3_Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enable RNA virus discovery.fasta

<p>The functions of RNA-dependent RNA polymerases (RdRps) in RNA viruses are demonstrably modulated by native substrates of dynamic and interconvertible conformational ensembles. Many of these are populated by essential flexible or intrinsically disordered regions (IDRs) that lack a stable thr...

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Bibliographic Details
Main Author: Rachid Tahzima (22106816) (author)
Other Authors: Justine Charon (6335501) (author), Adrian Diaz (7453568) (author), Kris De Jonghe (22106819) (author), Sebastien Massart (5601632) (author), Thierry Michon (1596172) (author), Wim Vranken (2337490) (author)
Published: 2025
Subjects:
Virology
RNA-dependent RNA polymerase
RNA virus discovery
conformational ensembles
intrinsic disorder (IDP/IDR)
structural biology
AlphaFold2 (AF2)
folding dynamics
modulome and artificial intelligence
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