ML trees of vIL-4 and interleukin-4 homologs from a selection of representative bird and reptilian genomes.

ML trees of vIL-4 and interleukin-4 homologs from a selection of representative bird and reptilian genomes.

<p>(A) From amino acid alignment, built with IQTREE using the ‘Q.bird+I+G4’ model as selected by ModelFinder, ultrafast bootstrapping (1000 iterations). (B) From coding nucleotide alignment, built with IQTREE using the ‘GTR+I+R’ model as selected by ModelFinder, ultrafast bootstrapping (1000 i...

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Bibliographic Details
Main Author: Jeremy D. Volkening (13030758) (author)
Other Authors: Stephen J. Spatz (4341484) (author), Maricarmen Garcia (21772671) (author), Teresa A. Ross (2066359) (author), Daniel A. Maekawa (21772674) (author), Kenneth S. Rosenthal (21772677) (author), Ana C. Zamora (21772680) (author), April Skipper (21772683) (author), Julia R. Blakey (21772686) (author), Rashan Paudel (21772689) (author)
Published: 2025
Subjects:
Medicine
Microbiology
Genetics
Evolutionary Biology
Immunology
Infectious Diseases
Virology
Biological Sciences not elsewhere classified
suggested direct capture
stimulation assay showed
natural cytokine signaling
macrophage cell line
length cdna sequencing
confirmed using lc
cell culture compared
intron gene structure
tertiary levels based
sequenced iltv genomes
infectious laryngotracheitis virus
enhance virus replication
conserved gene structure
div >< p
4 knockout compared
viral genome predicted
8 ), il
iltv genome expressing
recombinant chicken il
expressed viral il
viral il
4 gene
viral mimics
precisely conserved
highly expressed
comparable levels
5 ),
vertebrate il
functional il
vivo </
vivo ,</
vitro </
vertebrate interleukin
vertebrate homologs
subsequently identified
results represent
protein expression
phylogenetic analyses
persisting within
perpetuating strategies
parental strain
mature transcript
infected cells
immune response
galliformes </
functional interleukin
first report
computational modeling
cellular receptors
4 homologs
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Description
Summary:<p>(A) From amino acid alignment, built with IQTREE using the ‘Q.bird+I+G4’ model as selected by ModelFinder, ultrafast bootstrapping (1000 iterations). (B) From coding nucleotide alignment, built with IQTREE using the ‘GTR+I+R’ model as selected by ModelFinder, ultrafast bootstrapping (1000 iterations). Branches with UFBoot support (in red) < 90 were collapsed.</p>

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