Substituted Cysteine Modification and Anesthetic Protection (SCAMP) in α1A291Cβ3γ2L GABAA Receptors.

Each row depicts four voltage-clamped current traces recorded from a single oocyte expressing α1A291Cβ3γ2L GABAA receptors both before and after exposure to pCMBS alone (A; control) or together with one of the tested anesthetics (B-D; protection tests). Modification c...

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Bibliographic Details
Main Author:	Kieran Bhave (9234643) (author)
Other Authors:	Stuart A. Forman (649631) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Biotechnology Evolutionary Biology Cancer Infectious Diseases Computational Biology Chemical Sciences not elsewhere classified general anesthesia induced 8 residues located mpab binds selectively substituted cysteine modification pcmbs modification effects approaches also reveal acid level analysis homologous sites formed five homologous sites performed using etomidate synaptic αβγ gaba produced functional gaba outer transmembrane inter etomidate binds selectively control scamp studies 5 point mutations 3 &# 947 1 &# 946 &# 945 ;+ bnoh binds selectively xlink "> incorporation anesthetic photolabel ptfd synaptic gaba xlink "> functional analysis &# 947 &# 946 &# 945 photolabel incorporation anesthetic photolabel bind selectively etomidate sites pcmbs ). cysteine mutations approaches based subunit sites interfacial sites used voltage retained sensitivity positive modulation pentameric ligand inhibitory hetero electron micrography clamp electrophysiology bound ptfd bnoh modulation based largely </ sub
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Substituted Cysteine Modification and Anesthetic Protection (SCAMP) in α1A291Cβ3γ2L GABA<sub>A</sub> Receptors.

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