Figure S6 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors

<p>Supplemental Figure S6: In vivo efficacy of a range of doses of CLDN6-23-ADC in M202 xenograft models. ADC dosing is IV QW as indicated by the arrows</p>

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Egile nagusia: Martina S.J. McDermott (15206951) (author)
Beste egile batzuk: Neil A. O'Brien (15206954) (author), Benjamin Hoffstrom (15206957) (author), KeWei Gong (15206960) (author), Ming Lu (15206963) (author), Jun Zhang (15206966) (author), Tong Luo (15206969) (author), Min Liang (15206972) (author), Weiping Jia (15206975) (author), Jenny J. Hong (15206978) (author), Kevin Chau (15206981) (author), Simon Davenport (15206984) (author), Bin Xie (15206987) (author), Michael F. Press (15206990) (author), Richard Panayiotou (15206993) (author), Abram Handly-Santana (15206996) (author), Joan S. Brugge (9710515) (author), Leonard Presta (15206999) (author), John Glaspy (15207002) (author), Dennis J. Slamon (15047067) (author)
Argitaratua: 2025
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author Martina S.J. McDermott (15206951)
author2 Neil A. O'Brien (15206954)
Benjamin Hoffstrom (15206957)
KeWei Gong (15206960)
Ming Lu (15206963)
Jun Zhang (15206966)
Tong Luo (15206969)
Min Liang (15206972)
Weiping Jia (15206975)
Jenny J. Hong (15206978)
Kevin Chau (15206981)
Simon Davenport (15206984)
Bin Xie (15206987)
Michael F. Press (15206990)
Richard Panayiotou (15206993)
Abram Handly-Santana (15206996)
Joan S. Brugge (9710515)
Leonard Presta (15206999)
John Glaspy (15207002)
Dennis J. Slamon (15047067)
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author_facet Martina S.J. McDermott (15206951)
Neil A. O'Brien (15206954)
Benjamin Hoffstrom (15206957)
KeWei Gong (15206960)
Ming Lu (15206963)
Jun Zhang (15206966)
Tong Luo (15206969)
Min Liang (15206972)
Weiping Jia (15206975)
Jenny J. Hong (15206978)
Kevin Chau (15206981)
Simon Davenport (15206984)
Bin Xie (15206987)
Michael F. Press (15206990)
Richard Panayiotou (15206993)
Abram Handly-Santana (15206996)
Joan S. Brugge (9710515)
Leonard Presta (15206999)
John Glaspy (15207002)
Dennis J. Slamon (15047067)
author_role author
dc.creator.none.fl_str_mv Martina S.J. McDermott (15206951)
Neil A. O'Brien (15206954)
Benjamin Hoffstrom (15206957)
KeWei Gong (15206960)
Ming Lu (15206963)
Jun Zhang (15206966)
Tong Luo (15206969)
Min Liang (15206972)
Weiping Jia (15206975)
Jenny J. Hong (15206978)
Kevin Chau (15206981)
Simon Davenport (15206984)
Bin Xie (15206987)
Michael F. Press (15206990)
Richard Panayiotou (15206993)
Abram Handly-Santana (15206996)
Joan S. Brugge (9710515)
Leonard Presta (15206999)
John Glaspy (15207002)
Dennis J. Slamon (15047067)
dc.date.none.fl_str_mv 2025-11-25T13:00:32Z
dc.identifier.none.fl_str_mv 10.1158/1078-0432.30706649
dc.relation.none.fl_str_mv https://figshare.com/articles/figure/Figure_S6_from_Preclinical_Efficacy_of_the_Antibody_Drug_Conjugate_CLDN6_23-ADC_for_the_Treatment_of_CLDN6-Positive_Solid_Tumors/30706649
dc.rights.none.fl_str_mv CC BY
info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv Cancer
Therapeutic Research and Development
Biological Agents & Therapies
Antibody-drug conjugates
Gynecological Cancers
Endometrial cancer
Ovarian cancer
Translational Research
dc.title.none.fl_str_mv Figure S6 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
dc.type.none.fl_str_mv Image
Figure
info:eu-repo/semantics/publishedVersion
image
description <p>Supplemental Figure S6: In vivo efficacy of a range of doses of CLDN6-23-ADC in M202 xenograft models. ADC dosing is IV QW as indicated by the arrows</p>
eu_rights_str_mv openAccess
id Manara_a653a24b48a08c9e4d5aac112d6afffc
identifier_str_mv 10.1158/1078-0432.30706649
network_acronym_str Manara
network_name_str ManaraRepo
oai_identifier_str oai:figshare.com:article/30706649
publishDate 2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv CC BY
spelling Figure S6 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid TumorsMartina S.J. McDermott (15206951)Neil A. O'Brien (15206954)Benjamin Hoffstrom (15206957)KeWei Gong (15206960)Ming Lu (15206963)Jun Zhang (15206966)Tong Luo (15206969)Min Liang (15206972)Weiping Jia (15206975)Jenny J. Hong (15206978)Kevin Chau (15206981)Simon Davenport (15206984)Bin Xie (15206987)Michael F. Press (15206990)Richard Panayiotou (15206993)Abram Handly-Santana (15206996)Joan S. Brugge (9710515)Leonard Presta (15206999)John Glaspy (15207002)Dennis J. Slamon (15047067)CancerTherapeutic Research and DevelopmentBiological Agents & TherapiesAntibody-drug conjugatesGynecological CancersEndometrial cancerOvarian cancerTranslational Research<p>Supplemental Figure S6: In vivo efficacy of a range of doses of CLDN6-23-ADC in M202 xenograft models. ADC dosing is IV QW as indicated by the arrows</p>2025-11-25T13:00:32ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/1078-0432.30706649https://figshare.com/articles/figure/Figure_S6_from_Preclinical_Efficacy_of_the_Antibody_Drug_Conjugate_CLDN6_23-ADC_for_the_Treatment_of_CLDN6-Positive_Solid_Tumors/30706649CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307066492025-11-25T13:00:32Z
spellingShingle Figure S6 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
Martina S.J. McDermott (15206951)
Cancer
Therapeutic Research and Development
Biological Agents & Therapies
Antibody-drug conjugates
Gynecological Cancers
Endometrial cancer
Ovarian cancer
Translational Research
status_str publishedVersion
title Figure S6 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
title_full Figure S6 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
title_fullStr Figure S6 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
title_full_unstemmed Figure S6 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
title_short Figure S6 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
title_sort Figure S6 from Preclinical Efficacy of the Antibody–Drug Conjugate CLDN6–23-ADC for the Treatment of CLDN6-Positive Solid Tumors
topic Cancer
Therapeutic Research and Development
Biological Agents & Therapies
Antibody-drug conjugates
Gynecological Cancers
Endometrial cancer
Ovarian cancer
Translational Research