Everolimus decreased IgA1 deposits in glomeruli of α1KICD89Tg mice.

8-week-old α1KICD89Tg mice expressing human IgA1 and CD89 were used for testing everolimus as effective treatment with mTOR inhibitors (2 mg/kg/day; 10 mice) as compared to vehicle (10 mice). Glomeruli were stained with anti-human IgA1 antibodie...

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Bibliographic Details
Main Author:	Alexandra Cambier (22307216) (author)
Other Authors:	Jennifer Da Silva (17123326) (author), Julie Bex (22386141) (author), Fanny Canesi (22386144) (author), Lison Lachize Neanne (22386147) (author), Aurélie Sannier (22386150) (author), Hélène Mathieu (6433280) (author), Erwan Boedec (819298) (author), Amandine Badie (22386153) (author), Renato C. Monteiro (11550553) (author)
Published:	2025
Subjects:	Biochemistry Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Immunology Marine Biology Cancer Infectious Diseases Chemical Sciences not elsewhere classified western blot analysis systemic toxic effects steroids &# 8211 severe side effects novel therapeutic approach including detrimental impacts current immunosuppressive therapies circulating immune complexes alleviating disease manifestations renal failure worldwide everolimus treatment prevented everolimus impaired levels human mesangial cells slowing disease progression public igan dataset tg </ sup scd89 bind independently ki </ sup reverted mesangial iga1 modulating cd71 expression mesangial iga1 receptor igan expressing cd89 mesangial cells disease progression situ </ transferrin receptor renal function cd71 dysfunctions cd71 ), mtor expression reducing iga1 partite iga1 igan patients igan pathogenesis childhood igan xlink "> treated protocol single cell signaling pathway scd89 plays scd89 deposits scd89 ). rnaseq data recombinant scd89 preventive protocol pediatric patients pathogenic axis particularly crucial oral gavage mammalian target
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Everolimus decreased IgA1 deposits in glomeruli of α1<sup>KI</sup>CD89<sup>Tg</sup> mice.

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