Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and Analysis
<p>To systematically review and analyze reported cases of herpes zoster ophthalmicus (HZO)-related optic neuritis (ON) without retinal involvement, a potentially sight-threatening complication of varicella-zoster virus (VZV).</p> <p>A PRISMA-guided search of online databases from i...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , |
| Published: |
2025
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1852018243947986944 |
|---|---|
| author | Mahsa Pourmahdi-Boroujeni (21773169) |
| author2 | Bahareh Abtahi-Naeini (21773172) Fereshte Rastegarnasab (21773175) Kimia Afshar (21773178) Mohammadreza Akhlaghi (19236630) Mohsen Pourazizi (20391169) |
| author2_role | author author author author author |
| author_facet | Mahsa Pourmahdi-Boroujeni (21773169) Bahareh Abtahi-Naeini (21773172) Fereshte Rastegarnasab (21773175) Kimia Afshar (21773178) Mohammadreza Akhlaghi (19236630) Mohsen Pourazizi (20391169) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mahsa Pourmahdi-Boroujeni (21773169) Bahareh Abtahi-Naeini (21773172) Fereshte Rastegarnasab (21773175) Kimia Afshar (21773178) Mohammadreza Akhlaghi (19236630) Mohsen Pourazizi (20391169) |
| dc.date.none.fl_str_mv | 2025-07-23T20:20:05Z |
| dc.identifier.none.fl_str_mv | 10.6084/m9.figshare.29631033.v1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Optic_Neuritis_Associated_with_Herpes_Zoster_Ophthalmicus_A_Systematic_Review_and_Analysis/29631033 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Cell Biology Neuroscience Pharmacology Biotechnology Mental Health Infectious Diseases Virology Herpes zoster herpes zoster ophthalmicus optic neuritis systematic review |
| dc.title.none.fl_str_mv | Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and Analysis |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p>To systematically review and analyze reported cases of herpes zoster ophthalmicus (HZO)-related optic neuritis (ON) without retinal involvement, a potentially sight-threatening complication of varicella-zoster virus (VZV).</p> <p>A PRISMA-guided search of online databases from inception to January 31, 2025, identified case reports and series describing HZO-related ON without retinal involvement. Study quality was assessed using Joanna Briggs Institute checklists. Data on demographics, clinical features, diagnostics, treatments, and outcomes were analyzed using SPSS.</p> <p>Thirty-two studies (1919–2025) comprising 38 patients were included. The mean patient age was 52.6 years (ranging from 6 to 82), with a near-equal gender distribution. Comorbid conditions such as human immunodeficiency virus (HIV) infection, diabetes, and autoimmune disorders were noted in one-third of cases. ON most commonly presented unilaterally and ipsilateral to the dermatome of HZO. The mean interval from HZO onset to ON was approximately 22 days (ranging from 10 days prior to 150 days afterward). Blurred vision and eye pain were the most frequent symptoms. Common signs include visual field defect, congestion, mydriasis, and ophthalmoplegia. Keratitis was the most common observation in slit-lamp examination (62.8% (22 of 35 cases)). Corticosteroid therapy, including high-dose and pulse regimens, was administered in a third-fourth (28 of 38) of patients. In outcome assessment, 52.8% (19 of 36) achieved mild or no impairment, while 36.3% (12 of 36) experienced clinical blindness.</p> <p>HZO-related ON is an uncommon but significant sight-threatening complication in HZO. Timely diagnosis and appropriate antiviral treatment along with corticosteroid therapy may improve the visual prognosis.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_a67d64da8a7494dece340da7aa512d2a |
| identifier_str_mv | 10.6084/m9.figshare.29631033.v1 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/29631033 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and AnalysisMahsa Pourmahdi-Boroujeni (21773169)Bahareh Abtahi-Naeini (21773172)Fereshte Rastegarnasab (21773175)Kimia Afshar (21773178)Mohammadreza Akhlaghi (19236630)Mohsen Pourazizi (20391169)MedicineCell BiologyNeurosciencePharmacologyBiotechnologyMental HealthInfectious DiseasesVirologyHerpes zosterherpes zoster ophthalmicusoptic neuritissystematic review<p>To systematically review and analyze reported cases of herpes zoster ophthalmicus (HZO)-related optic neuritis (ON) without retinal involvement, a potentially sight-threatening complication of varicella-zoster virus (VZV).</p> <p>A PRISMA-guided search of online databases from inception to January 31, 2025, identified case reports and series describing HZO-related ON without retinal involvement. Study quality was assessed using Joanna Briggs Institute checklists. Data on demographics, clinical features, diagnostics, treatments, and outcomes were analyzed using SPSS.</p> <p>Thirty-two studies (1919–2025) comprising 38 patients were included. The mean patient age was 52.6 years (ranging from 6 to 82), with a near-equal gender distribution. Comorbid conditions such as human immunodeficiency virus (HIV) infection, diabetes, and autoimmune disorders were noted in one-third of cases. ON most commonly presented unilaterally and ipsilateral to the dermatome of HZO. The mean interval from HZO onset to ON was approximately 22 days (ranging from 10 days prior to 150 days afterward). Blurred vision and eye pain were the most frequent symptoms. Common signs include visual field defect, congestion, mydriasis, and ophthalmoplegia. Keratitis was the most common observation in slit-lamp examination (62.8% (22 of 35 cases)). Corticosteroid therapy, including high-dose and pulse regimens, was administered in a third-fourth (28 of 38) of patients. In outcome assessment, 52.8% (19 of 36) achieved mild or no impairment, while 36.3% (12 of 36) experienced clinical blindness.</p> <p>HZO-related ON is an uncommon but significant sight-threatening complication in HZO. Timely diagnosis and appropriate antiviral treatment along with corticosteroid therapy may improve the visual prognosis.</p>2025-07-23T20:20:05ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.6084/m9.figshare.29631033.v1https://figshare.com/articles/dataset/Optic_Neuritis_Associated_with_Herpes_Zoster_Ophthalmicus_A_Systematic_Review_and_Analysis/29631033CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/296310332025-07-23T20:20:05Z |
| spellingShingle | Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and Analysis Mahsa Pourmahdi-Boroujeni (21773169) Medicine Cell Biology Neuroscience Pharmacology Biotechnology Mental Health Infectious Diseases Virology Herpes zoster herpes zoster ophthalmicus optic neuritis systematic review |
| status_str | publishedVersion |
| title | Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and Analysis |
| title_full | Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and Analysis |
| title_fullStr | Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and Analysis |
| title_full_unstemmed | Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and Analysis |
| title_short | Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and Analysis |
| title_sort | Optic Neuritis Associated with Herpes Zoster Ophthalmicus: A Systematic Review and Analysis |
| topic | Medicine Cell Biology Neuroscience Pharmacology Biotechnology Mental Health Infectious Diseases Virology Herpes zoster herpes zoster ophthalmicus optic neuritis systematic review |