Role of Q103A residue in vWbp-mediated cross-linking of FnBPA to fibrin(ogen).

<p>(A–B) Cross-link formation of recombinant N1N2N3 domain of FnBPA WT (A) or Q103A mutant (B) to fibrin(ogen) by vWbp-activated FXIII was analyzed by Western Blotting. Reaction mixtures were incubated for increasing time points (0–120 min) in the presence of calcium, separated by SDS-PAGE und...

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主要作者:	Chiara Motta (16015211) (author)
其他作者:	Mary Turley (22756239) (author), Giulia Barbieri (7055000) (author), Agata Famà (10974896) (author), Francesco Coppolino (8615506) (author), Elisa Bellan Menegussi (22756242) (author), Joan A. Geoghegan (7934549) (author), Concetta Beninati (166964) (author), Angelica Pellegrini (12472515) (author), Giampiero Pietrocola (424821) (author)
出版:	2025
主題:	Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Immunology Cancer Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified new virulence strategy murine infection model life threatening diseases human factor xiii cause different types broader physiological relevance evade host immunity lower bacterial loads bacterial surface proteins new pathogenic mechanism form covalent complexes host protein complexes uses host transglutaminases fibronectin binding protein staphylococcus aureus </ mediated fibrin crosslinking binding protein mediated crosslinking aureus </ host tissues stabilizing bacterial latch mechanism vivo </ uses vwbp covalent fnbpa various tissues type strain skin lesions similar pathway retained non results show opportunistic pathogen ogen ). n1 subdomain less virulent fibrin matrices extracellular matrix effective adhesion covalently anchor classical dock
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Role of Q103A residue in vWbp-mediated cross-linking of FnBPA to fibrin(ogen).

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