Replication stress leads to ssDNA accumulation, which affects the mechanisms influencing cell cycle progression in mycATRΔC-/- cells.

<p>(A) Representative images acquired by a LSM880 Zeiss confocal microscope from Z stack images of mycATRΔC-/- cells (cl8) untreated (NT) or treated with 5 mM of HU for 5 hours. Previously, cells were incubated with 150 µM of IdU for 16 hours for DNA labelling. Cells were fixed with 3% formald...

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Autor principal:	Gabriel L. A. da Silva (22676649) (author)
Altres autors:	Jeziel D. Damasceno (9073663) (author), Jennifer A. Black (14411790) (author), Craig Lapsley (6082646) (author), Richard McCulloch (12918) (author), Luiz R. O. Tosi (9073666) (author)
Publicat:	2025
Matèries:	Biophysics Biochemistry Microbiology Cell Biology Genetics Molecular Biology Developmental Biology Science Policy Infectious Diseases Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified major &# 8217 div >< p data reveals loss cells possess mechanisms remarkably plastic genome cas9 genome editing like family acts protein kinase ataxia atr depends upon delayed dna replication stranded dna accumulation leishmania major </ dna damage kinase dna damage genome stability leishmania </ dna metabolism dna injuries atr acts replication stress replication impediments work shows whose integrity terminal knockout smaller chromosomes protozoan parasite phosphatidylinositol 3 nuclear localisation mycatrδc -/-). mycatr ), master regulator larger chromosomes key role increased levels functional relevance eukaryotic response deletion results constantly challenged atr plays atr homolog atr ),
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Replication stress leads to ssDNA accumulation, which affects the mechanisms influencing cell cycle progression in mycATRΔC-/- cells.

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