Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation

Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation

<p><i>(a)</i> Local electrical stimulation (i.e. Schaffer collateral synaptic stimulation) regions (blue purple and magenta) shown on schematic. There is no somatic stimulation. <i>(b)</i> Schaffer collateral weight change for 900 pulses delivered at 1, 10, 30, and 100...

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Bibliografiska uppgifter
Huvudupphovsman: Nicholas Hananeia (22683665) (author)
Övriga upphovsmän: Christian Ebner (1276467) (author), Christos Galanis (15210328) (author), Hermann Cuntz (32618) (author), Alexander Opitz (295799) (author), Andreas Vlachos (47497) (author), Peter Jedlicka (179938) (author)
Publicerad: 2025
Ämnen:
Medicine
Cell Biology
Neuroscience
Physiology
Space Science
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
results :</ b
previous experimental studies
objective :</ b
methods :</ b
like cellular effects
conclusion :</ b
background :</ b
strongly distance dependent
scale modeling tools
repetitive magnetic stimulation
biophysical neuronal models
1 hz protocols
successfully modelled plasticity
induced synaptic plasticity
dependent plasticity model
plasticity model
dependent spatio
scale modelling
burst stimulation
5 hz
plasticity amplitude
distal plasticity
term potentiation
term changes
temporal resolution
temporal changes
rms ).
previously established
parameter screening
neurons stimulated
neuronal dendrites
modelling framework
mechanisms behind
low sensitivity
high spatio
fully understood
detailed prediction
dendritic spikes
comprehensive module
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Sammanfattning:<p><i>(a)</i> Local electrical stimulation (i.e. Schaffer collateral synaptic stimulation) regions (blue purple and magenta) shown on schematic. There is no somatic stimulation. <i>(b)</i> Schaffer collateral weight change for 900 pulses delivered at 1, 10, 30, and 100 Hz with inhibition active. Model (red) and data (black). <i>(c)</i> Same as b but with inhibition blocked. Model (red) and bicuculline data (black).</p>

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