Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation
<p><i>(a)</i> Local electrical stimulation (i.e. Schaffer collateral synaptic stimulation) regions (blue purple and magenta) shown on schematic. There is no somatic stimulation. <i>(b)</i> Schaffer collateral weight change for 900 pulses delivered at 1, 10, 30, and 100...
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2025
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| _version_ | 1849927626282500096 |
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| author | Nicholas Hananeia (22683665) |
| author2 | Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| author2_role | author author author author author author |
| author_facet | Nicholas Hananeia (22683665) Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nicholas Hananeia (22683665) Christian Ebner (1276467) Christos Galanis (15210328) Hermann Cuntz (32618) Alexander Opitz (295799) Andreas Vlachos (47497) Peter Jedlicka (179938) |
| dc.date.none.fl_str_mv | 2025-11-25T18:42:04Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pcbi.1012295.g002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Unifying_four-pathway_model_of_long-term_synaptic_plasticity_reproduces_frequency_dependence_of_synaptic_changes_in_hippocampal_CA1_pyramidal_cells_evoked_by_local_electrical_Schaffer_collateral_stimulation/30715016 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |
| dc.title.none.fl_str_mv | Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><i>(a)</i> Local electrical stimulation (i.e. Schaffer collateral synaptic stimulation) regions (blue purple and magenta) shown on schematic. There is no somatic stimulation. <i>(b)</i> Schaffer collateral weight change for 900 pulses delivered at 1, 10, 30, and 100 Hz with inhibition active. Model (red) and data (black). <i>(c)</i> Same as b but with inhibition blocked. Model (red) and bicuculline data (black).</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_a9da8e1773079c64e409f3b3e69f3c3c |
| identifier_str_mv | 10.1371/journal.pcbi.1012295.g002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30715016 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulationNicholas Hananeia (22683665)Christian Ebner (1276467)Christos Galanis (15210328)Hermann Cuntz (32618)Alexander Opitz (295799)Andreas Vlachos (47497)Peter Jedlicka (179938)MedicineCell BiologyNeurosciencePhysiologySpace ScienceBiological Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedresults :</ bprevious experimental studiesobjective :</ bmethods :</ blike cellular effectsconclusion :</ bbackground :</ bstrongly distance dependentscale modeling toolsrepetitive magnetic stimulationbiophysical neuronal models1 hz protocolssuccessfully modelled plasticityinduced synaptic plasticitydependent plasticity modelplasticity modeldependent spatioscale modellingburst stimulation5 hzplasticity amplitudedistal plasticityterm potentiationterm changestemporal resolutiontemporal changesrms ).previously establishedparameter screeningneurons stimulatedneuronal dendritesmodelling frameworkmechanisms behindlow sensitivityhigh spatiofully understooddetailed predictiondendritic spikescomprehensive module<p><i>(a)</i> Local electrical stimulation (i.e. Schaffer collateral synaptic stimulation) regions (blue purple and magenta) shown on schematic. There is no somatic stimulation. <i>(b)</i> Schaffer collateral weight change for 900 pulses delivered at 1, 10, 30, and 100 Hz with inhibition active. Model (red) and data (black). <i>(c)</i> Same as b but with inhibition blocked. Model (red) and bicuculline data (black).</p>2025-11-25T18:42:04ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pcbi.1012295.g002https://figshare.com/articles/figure/Unifying_four-pathway_model_of_long-term_synaptic_plasticity_reproduces_frequency_dependence_of_synaptic_changes_in_hippocampal_CA1_pyramidal_cells_evoked_by_local_electrical_Schaffer_collateral_stimulation/30715016CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307150162025-11-25T18:42:04Z |
| spellingShingle | Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation Nicholas Hananeia (22683665) Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |
| status_str | publishedVersion |
| title | Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation |
| title_full | Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation |
| title_fullStr | Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation |
| title_full_unstemmed | Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation |
| title_short | Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation |
| title_sort | Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation |
| topic | Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module |