Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation

(a) Local electrical stimulation (i.e. Schaffer collateral synaptic stimulation) regions (blue purple and magenta) shown on schematic. There is no somatic stimulation. (b) Schaffer collateral weight change for 900 pulses delivered at 1, 10, 30, and 100...

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Detalhes bibliográficos
Autor principal:	Nicholas Hananeia (22683665) (author)
Outros Autores:	Christian Ebner (1276467) (author), Christos Galanis (15210328) (author), Hermann Cuntz (32618) (author), Alexander Opitz (295799) (author), Andreas Vlachos (47497) (author), Peter Jedlicka (179938) (author)
Publicado em:	2025
Assuntos:	Medicine Cell Biology Neuroscience Physiology Space Science Biological Sciences not elsewhere classified Information Systems not elsewhere classified results :</ b previous experimental studies objective :</ b methods :</ b like cellular effects conclusion :</ b background :</ b strongly distance dependent scale modeling tools repetitive magnetic stimulation biophysical neuronal models 1 hz protocols successfully modelled plasticity induced synaptic plasticity dependent plasticity model plasticity model dependent spatio scale modelling burst stimulation 5 hz plasticity amplitude distal plasticity term potentiation term changes temporal resolution temporal changes rms ). previously established parameter screening neurons stimulated neuronal dendrites modelling framework mechanisms behind low sensitivity high spatio fully understood detailed prediction dendritic spikes comprehensive module
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Unifying four-pathway model of long-term synaptic plasticity reproduces frequency dependence of synaptic changes in hippocampal CA1 pyramidal cells evoked by local electrical Schaffer collateral stimulation

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