Site-Specific Chemoselective Cyclization and Fluorogenic Modification of Protein Cysteine Residues: From Side-Chain to Backbone

The selective modification of natural protein templates has emerged as a powerful tool for investigating the protein structure and function as well as for designing therapeutic bioconjugates. While significant progress has been made in modifying protein side chains and terminal groups, backbone modi...

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Autor principal:	Hui Zhang (7197) (author)
Altres autors:	Ke Wei (192091) (author), Wanyi Yu (19740353) (author), Youshen Wu (819594) (author), Xuhong Qian (1409410) (author), Eric V. Anslyn (1349271) (author), Xiaolong Sun (1726846) (author)
Publicat:	2025
Matèries:	Biophysics Biochemistry Genetics Molecular Biology Biotechnology Sociology Inorganic Chemistry Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified peptide functional studies membered heterocyclic unit hydrogen bond disruption enzymatic activity induced molecule cysteine mimics cyclization reactions driven protein thermal stability natural protein templates designing therapeutic bioconjugates specific chemical modifications protein cysteine residues unique strategy offers molecular conjugate acceptor local backbone torsion achieving site specificity selective chemical modification specific chemoselective cyclization conjugate acceptor selective modification intramolecular cyclization cysteine residue unique reactivity step strategy protein structure potential protein novel bioconjugates fluorogenic modification backbone modification terminal groups situ monitoring significant progress protein function preliminary investigations powerful tool physiological conditions new platform inherent inertness fluorogenic labeling fluorescence turn first couple critical role consequent changes approach leverages amine coupling amide bonds adjacent amide
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Site-Specific Chemoselective Cyclization and Fluorogenic Modification of Protein Cysteine Residues: From Side-Chain to Backbone

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