Low iron activates Furin which sheds to cleave the prodomain of ADAM10 rendering it activated.

<p><b>(A.i.)</b> Western blot of whole cell lysate of uninfected-MФs, LD-R, and LD-S infected-MФs at 24 hrs pi showing the expression of precursor-ADAM10 (p-ADAM10, ~90 kDa) and mature-ADAM10 (m-ADAM10, ~64 kDa) keeping β-actin acts as a housekeeping control. <b>(A.ii.)</b...

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Bibliographic Details
Main Author:	Souradeepa Ghosh (14276657) (author)
Other Authors:	Krishna Vamshi Chigicherla (20649145) (author), Shirin Dasgupta (20649148) (author), Yasuyuki Goto (22965) (author), Budhaditya Mukherjee (106862) (author)
Published:	2025
Subjects:	Biochemistry Medicine Microbiology Cell Biology Biotechnology Evolutionary Biology Ecology Inorganic Chemistry Hematology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified unresponsiveness points towards treating visceral leishmaniasis sustaining heightened levels selectively reshuffling macrophage recent clinical isolates leishmania donovani </ inherent metabolic shift even though anti div >< p surface iron exporter subsequent iron insufficiency higher iron utilization triggering oxidative outburst gained increased potential withstand elevated ros elevated ros levels pv thereby gaining pentavalent antimonials relies surplus iron iron within oxidative stress increased erythrophagocytosis two proteases survival edge surprising strategy study highlights sensitive counterparts parasitophorous vacuoles leishmanial activity intracellular pathogens infected macrophages genetic adaptation evolutionary persistence complex interplay cd47 surveillance aggressive proliferation
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Low iron activates Furin which sheds to cleave the prodomain of ADAM10 rendering it activated.

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