Figure 4 from Bcl-xL Is a Key Mediator of Apoptosis Following KRAS<sup>G12C</sup> Inhibition in <i>KRAS<sup>G12C</sup></i>-mutant Colorectal Cancer

Figure 4 from Bcl-xL Is a Key Mediator of Apoptosis Following KRAS<sup>G12C</sup> Inhibition in <i>KRAS<sup>G12C</sup></i>-mutant Colorectal Cancer

<p>High-throughput drug screen reveals that pharmacologic inhibition of Bcl-xL synergizes with KRAS<sup>G12C</sup> inhibition in <i>KRAS</i><sup>G12C</sup> MT colorectal cancer. <b>A,</b> SW837 and SNU1411 cells were cotreated with 1 μmol/L AZ’15...

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Главный автор:	Hajrah Khawaja (15090810) (author)
Другие авторы:	Rebecca Briggs (15090813) (author), Cheryl H. Latimer (15090816) (author), Mustasin Rassel (15090819) (author), Daryl Griffin (15090822) (author), Lyndsey Hanson (15090825) (author), Alberto Bardelli (15046646) (author), Frederica Di Nicolantonio (15090828) (author), Simon S. McDade (14939679) (author), Christopher J. Scott (15090831) (author), Shauna Lambe (15090834) (author), Manisha Maurya (15090837) (author), Andreas U. Lindner (15033719) (author), Jochen H.M. Prehn (15033731) (author), Jose Sousa (15090840) (author), Chris Winnington (15090843) (author), Melissa J. LaBonte (15090846) (author), Sarah Ross (15090849) (author), Sandra Van Schaeybroeck (15090852) (author)
Опубликовано:	2025
Предметы:	Cancer Cancer Biology Therapeutic Research and Development Drug Resistance Novel mechanisms Gastrointestinal Cancers Colorectal cancer Oncogenes & Tumor Suppressors Kras
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