Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs Carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots

Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs Carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots

Tissue plasminogen activator (tPA) is the sole approved therapeutic molecule for the treatment of acute ischemic stroke. Yet, only a small percentage of patients could benefit from this life-saving treatment because of medical contraindications and severe side effects, including brain hemorrhage, as...

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Bibliographic Details
Main Author: Marianna Colasuonno (5982593) (author)
Other Authors: Anna Lisa Palange (1454770) (author), Rachida Aid (5982596) (author), Miguel Ferreira (4768773) (author), Hilaria Mollica (5982599) (author), Roberto Palomba (1341129) (author), Michele Emdin (522509) (author), Massimo Del Sette (5982602) (author), Cédric Chauvierre (5982605) (author), Didier Letourneur (647133) (author), Paolo Decuzzi (382033) (author)
Published: 2018
Subjects:
Biochemistry
Medicine
Cell Biology
Genetics
Molecular Biology
Physiology
Pharmacology
Sociology
Cancer
Hematology
Virology
Mathematical Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Tissue Plasminogen Activator
tPA-DPN
60 min post-treatment initiation
murine mesentery venules
lytic activity
clot area reduction
tPA
DPN
Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs
Blood Clots Tissue plasminogen activator
blood clot dissolution
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