D4 b2AR pathway implemented in ODE format compatible with SBML.
<p>Blocks and quotient graph are computed by automated hierarchical decomposition. (A) <i>r</i>-blocks and quotient graph after Michaelis-Menten type reduction. One has the same blocks for <i>r</i> = 1, 2. (B) <i>r</i>-blocks and reaction bipartite graph. Fo...
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2024
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| _version_ | 1852024777924935680 |
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| author | Nisha Ann Viswan (20371285) |
| author2 | Alexandre Tribut (20371288) Manvel Gasparyan (14250300) Ovidiu Radulescu (266188) Upinder S. Bhalla (11768249) |
| author2_role | author author author author |
| author_facet | Nisha Ann Viswan (20371285) Alexandre Tribut (20371288) Manvel Gasparyan (14250300) Ovidiu Radulescu (266188) Upinder S. Bhalla (11768249) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nisha Ann Viswan (20371285) Alexandre Tribut (20371288) Manvel Gasparyan (14250300) Ovidiu Radulescu (266188) Upinder S. Bhalla (11768249) |
| dc.date.none.fl_str_mv | 2024-12-02T19:07:26Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pcbi.1012624.g005 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/D4_b2AR_pathway_implemented_in_ODE_format_compatible_with_SBML_/27947104 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Ecology Plant Biology Computational Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Information Systems not elsewhere classified huge parameter space given biochemical network frequently encounter multiscale subsequent levels rely necessary nested hierarchies extensive systems models systems simulations succeeding levels nested hierarchy sparse data solution degeneracy signalling inputs results indicate preceding ones pathway serves multiphysics phenomena mathematical basis intermediate stages independent pathway held constant first level every level based simulations algorithmic approach |
| dc.title.none.fl_str_mv | D4 b2AR pathway implemented in ODE format compatible with SBML. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Blocks and quotient graph are computed by automated hierarchical decomposition. (A) <i>r</i>-blocks and quotient graph after Michaelis-Menten type reduction. One has the same blocks for <i>r</i> = 1, 2. (B) <i>r</i>-blocks and reaction bipartite graph. For the decompositon, we have considered that the reaction is forward irreversible. The forward irreversibility conditions were verified by numerical simulations.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_ac3bd91dcb8082af899f00a0e3544852 |
| identifier_str_mv | 10.1371/journal.pcbi.1012624.g005 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/27947104 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | D4 b2AR pathway implemented in ODE format compatible with SBML.Nisha Ann Viswan (20371285)Alexandre Tribut (20371288)Manvel Gasparyan (14250300)Ovidiu Radulescu (266188)Upinder S. Bhalla (11768249)EcologyPlant BiologyComputational BiologyBiological Sciences not elsewhere classifiedMathematical Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedhuge parameter spacegiven biochemical networkfrequently encounter multiscalesubsequent levels relynecessary nested hierarchiesextensive systems modelssystems simulationssucceeding levelsnested hierarchysparse datasolution degeneracysignalling inputsresults indicatepreceding onespathway servesmultiphysics phenomenamathematical basisintermediate stagesindependent pathwayheld constantfirst levelevery levelbased simulationsalgorithmic approach<p>Blocks and quotient graph are computed by automated hierarchical decomposition. (A) <i>r</i>-blocks and quotient graph after Michaelis-Menten type reduction. One has the same blocks for <i>r</i> = 1, 2. (B) <i>r</i>-blocks and reaction bipartite graph. For the decompositon, we have considered that the reaction is forward irreversible. The forward irreversibility conditions were verified by numerical simulations.</p>2024-12-02T19:07:26ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pcbi.1012624.g005https://figshare.com/articles/figure/D4_b2AR_pathway_implemented_in_ODE_format_compatible_with_SBML_/27947104CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279471042024-12-02T19:07:26Z |
| spellingShingle | D4 b2AR pathway implemented in ODE format compatible with SBML. Nisha Ann Viswan (20371285) Ecology Plant Biology Computational Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Information Systems not elsewhere classified huge parameter space given biochemical network frequently encounter multiscale subsequent levels rely necessary nested hierarchies extensive systems models systems simulations succeeding levels nested hierarchy sparse data solution degeneracy signalling inputs results indicate preceding ones pathway serves multiphysics phenomena mathematical basis intermediate stages independent pathway held constant first level every level based simulations algorithmic approach |
| status_str | publishedVersion |
| title | D4 b2AR pathway implemented in ODE format compatible with SBML. |
| title_full | D4 b2AR pathway implemented in ODE format compatible with SBML. |
| title_fullStr | D4 b2AR pathway implemented in ODE format compatible with SBML. |
| title_full_unstemmed | D4 b2AR pathway implemented in ODE format compatible with SBML. |
| title_short | D4 b2AR pathway implemented in ODE format compatible with SBML. |
| title_sort | D4 b2AR pathway implemented in ODE format compatible with SBML. |
| topic | Ecology Plant Biology Computational Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Information Systems not elsewhere classified huge parameter space given biochemical network frequently encounter multiscale subsequent levels rely necessary nested hierarchies extensive systems models systems simulations succeeding levels nested hierarchy sparse data solution degeneracy signalling inputs results indicate preceding ones pathway serves multiphysics phenomena mathematical basis intermediate stages independent pathway held constant first level every level based simulations algorithmic approach |