Integrated workflow for organism-level phenotyping and machine-learning inference.
<p>Workflow schematic: (i) establish a non-adverse exposure using hatching, malformation, and survival endpoints; (ii) record behavioral (tail-swing), cardiac (heart rate), and brain-wide neural activity readouts; (iii) integrate features and perform machine-learning-based clustering against a...
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2025
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| _version_ | 1849927643719270400 |
|---|---|
| author | Zhuangbin Zheng (22676304) |
| author2 | Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470) |
| author2_role | author author author author author author |
| author_facet | Zhuangbin Zheng (22676304) Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470) |
| author_role | author |
| dc.creator.none.fl_str_mv | Zhuangbin Zheng (22676304) Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470) |
| dc.date.none.fl_str_mv | 2025-11-24T18:22:38Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0336479.g004 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Integrated_workflow_for_organism-level_phenotyping_and_machine-learning_inference_/30696447 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration |
| dc.title.none.fl_str_mv | Integrated workflow for organism-level phenotyping and machine-learning inference. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Workflow schematic: (i) establish a non-adverse exposure using hatching, malformation, and survival endpoints; (ii) record behavioral (tail-swing), cardiac (heart rate), and brain-wide neural activity readouts; (iii) integrate features and perform machine-learning-based clustering against a reference drug database to infer functional similarity.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_acdc0f79b62d65cc65b90c9ded2284cc |
| identifier_str_mv | 10.1371/journal.pone.0336479.g004 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30696447 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Integrated workflow for organism-level phenotyping and machine-learning inference.Zhuangbin Zheng (22676304)Fanlei Ran (7352957)Lushan Liang (22676307)Yiqian Zhang (752795)Xianwen Li (3910537)Liqun Zhang (115900)Lijun Bi (121470)PharmacologyBiotechnologyEvolutionary BiologyImmunologyInfectious DiseasesBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedtotal antioxidant capacityrecent studies indicateprior preparation workpollutant degradation owinglarva zebrafish (<high reducing powerdanio rerio </ebl ), referencetransiently generated ediv >< p1 mv ),biomedical effects studylevel effectsebl ’biomedical potentialbiomedical applicationwidely studieduric acidreduction potentialprecluding storageph 13orp 47new potentialshypoglycemic drugshydrated electronsfindings motivatebiological investigationadverse concentration<p>Workflow schematic: (i) establish a non-adverse exposure using hatching, malformation, and survival endpoints; (ii) record behavioral (tail-swing), cardiac (heart rate), and brain-wide neural activity readouts; (iii) integrate features and perform machine-learning-based clustering against a reference drug database to infer functional similarity.</p>2025-11-24T18:22:38ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0336479.g004https://figshare.com/articles/figure/Integrated_workflow_for_organism-level_phenotyping_and_machine-learning_inference_/30696447CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306964472025-11-24T18:22:38Z |
| spellingShingle | Integrated workflow for organism-level phenotyping and machine-learning inference. Zhuangbin Zheng (22676304) Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration |
| status_str | publishedVersion |
| title | Integrated workflow for organism-level phenotyping and machine-learning inference. |
| title_full | Integrated workflow for organism-level phenotyping and machine-learning inference. |
| title_fullStr | Integrated workflow for organism-level phenotyping and machine-learning inference. |
| title_full_unstemmed | Integrated workflow for organism-level phenotyping and machine-learning inference. |
| title_short | Integrated workflow for organism-level phenotyping and machine-learning inference. |
| title_sort | Integrated workflow for organism-level phenotyping and machine-learning inference. |
| topic | Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration |