One variant per line data for interfering substance study.
<p>One variant per line data for interfering substance study.</p>
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2025
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| _version_ | 1852014774808739840 |
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| author | Wenshu Li (762627) |
| author2 | Jeffrey A. Leibowitz (22634004) Shuoguo Wang (189094) Louisa Walker (22634007) Chang Xu (102022) Kuei-Ting Chen (22634010) Alexa B. Schrock (11359638) Jason Hughes (7601516) Nimesh Patel (3407483) Julia A. Elvin (14930571) Lauren L. Ritterhouse (7553384) Ethan Sokol (3548789) Garrett Frampton (7374938) Lucas Dennis (599740) Bahar Yilmazel (22634013) Brennan Decker (145811) |
| author2_role | author author author author author author author author author author author author author author author |
| author_facet | Wenshu Li (762627) Jeffrey A. Leibowitz (22634004) Shuoguo Wang (189094) Louisa Walker (22634007) Chang Xu (102022) Kuei-Ting Chen (22634010) Alexa B. Schrock (11359638) Jason Hughes (7601516) Nimesh Patel (3407483) Julia A. Elvin (14930571) Lauren L. Ritterhouse (7553384) Ethan Sokol (3548789) Garrett Frampton (7374938) Lucas Dennis (599740) Bahar Yilmazel (22634013) Brennan Decker (145811) |
| author_role | author |
| dc.creator.none.fl_str_mv | Wenshu Li (762627) Jeffrey A. Leibowitz (22634004) Shuoguo Wang (189094) Louisa Walker (22634007) Chang Xu (102022) Kuei-Ting Chen (22634010) Alexa B. Schrock (11359638) Jason Hughes (7601516) Nimesh Patel (3407483) Julia A. Elvin (14930571) Lauren L. Ritterhouse (7553384) Ethan Sokol (3548789) Garrett Frampton (7374938) Lucas Dennis (599740) Bahar Yilmazel (22634013) Brennan Decker (145811) |
| dc.date.none.fl_str_mv | 2025-11-17T18:40:08Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0336940.s005 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/One_variant_per_line_data_for_interfering_substance_study_/30642095 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Cell Biology Genetics Molecular Biology Biotechnology Cancer Virology Biological Sciences not elsewhere classified sequencers yielded agreement normal tissue specimens foundationone &# 174 ensure chromosomal integrity copy number features negative percent agreement negative samples showed validation results underscore positive percent agreement hrr gene alterations independent hrd biomarker 278 solid tumor high analytical concordance analytical validation tumor biomarker negative replicates spiked samples tumor purity hrdsig results targeted therapies sister chromatid sensitize tumors score based reproducibility testing reliable assessment reagent lots positive rate polymerase inhibitors overall robustness oscillation patterns may benefit low false interfering substances identify patients hrr pathway hrd signature epigenetic mechanisms dna scar demonstrating 100 certified laboratory cellular pathway cell viability based chemotherapy based approach 44 %. 126 hrd 11 positive 100 hrd |
| dc.title.none.fl_str_mv | One variant per line data for interfering substance study. |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p>One variant per line data for interfering substance study.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_ad080277f46003cffca90cf0ff8a1206 |
| identifier_str_mv | 10.1371/journal.pone.0336940.s005 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30642095 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | One variant per line data for interfering substance study.Wenshu Li (762627)Jeffrey A. Leibowitz (22634004)Shuoguo Wang (189094)Louisa Walker (22634007)Chang Xu (102022)Kuei-Ting Chen (22634010)Alexa B. Schrock (11359638)Jason Hughes (7601516)Nimesh Patel (3407483)Julia A. Elvin (14930571)Lauren L. Ritterhouse (7553384)Ethan Sokol (3548789)Garrett Frampton (7374938)Lucas Dennis (599740)Bahar Yilmazel (22634013)Brennan Decker (145811)MedicineCell BiologyGeneticsMolecular BiologyBiotechnologyCancerVirologyBiological Sciences not elsewhere classifiedsequencers yielded agreementnormal tissue specimensfoundationone &# 174ensure chromosomal integritycopy number featuresnegative percent agreementnegative samples showedvalidation results underscorepositive percent agreementhrr gene alterationsindependent hrd biomarker278 solid tumorhigh analytical concordanceanalytical validationtumor biomarkernegative replicatesspiked samplestumor purityhrdsig resultstargeted therapiessister chromatidsensitize tumorsscore basedreproducibility testingreliable assessmentreagent lotspositive ratepolymerase inhibitorsoverall robustnessoscillation patternsmay benefitlow falseinterfering substancesidentify patientshrr pathwayhrd signatureepigenetic mechanismsdna scardemonstrating 100certified laboratorycellular pathwaycell viabilitybased chemotherapybased approach44 %.126 hrd11 positive100 hrd<p>One variant per line data for interfering substance study.</p>2025-11-17T18:40:08ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.1371/journal.pone.0336940.s005https://figshare.com/articles/dataset/One_variant_per_line_data_for_interfering_substance_study_/30642095CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306420952025-11-17T18:40:08Z |
| spellingShingle | One variant per line data for interfering substance study. Wenshu Li (762627) Medicine Cell Biology Genetics Molecular Biology Biotechnology Cancer Virology Biological Sciences not elsewhere classified sequencers yielded agreement normal tissue specimens foundationone &# 174 ensure chromosomal integrity copy number features negative percent agreement negative samples showed validation results underscore positive percent agreement hrr gene alterations independent hrd biomarker 278 solid tumor high analytical concordance analytical validation tumor biomarker negative replicates spiked samples tumor purity hrdsig results targeted therapies sister chromatid sensitize tumors score based reproducibility testing reliable assessment reagent lots positive rate polymerase inhibitors overall robustness oscillation patterns may benefit low false interfering substances identify patients hrr pathway hrd signature epigenetic mechanisms dna scar demonstrating 100 certified laboratory cellular pathway cell viability based chemotherapy based approach 44 %. 126 hrd 11 positive 100 hrd |
| status_str | publishedVersion |
| title | One variant per line data for interfering substance study. |
| title_full | One variant per line data for interfering substance study. |
| title_fullStr | One variant per line data for interfering substance study. |
| title_full_unstemmed | One variant per line data for interfering substance study. |
| title_short | One variant per line data for interfering substance study. |
| title_sort | One variant per line data for interfering substance study. |
| topic | Medicine Cell Biology Genetics Molecular Biology Biotechnology Cancer Virology Biological Sciences not elsewhere classified sequencers yielded agreement normal tissue specimens foundationone &# 174 ensure chromosomal integrity copy number features negative percent agreement negative samples showed validation results underscore positive percent agreement hrr gene alterations independent hrd biomarker 278 solid tumor high analytical concordance analytical validation tumor biomarker negative replicates spiked samples tumor purity hrdsig results targeted therapies sister chromatid sensitize tumors score based reproducibility testing reliable assessment reagent lots positive rate polymerase inhibitors overall robustness oscillation patterns may benefit low false interfering substances identify patients hrr pathway hrd signature epigenetic mechanisms dna scar demonstrating 100 certified laboratory cellular pathway cell viability based chemotherapy based approach 44 %. 126 hrd 11 positive 100 hrd |