Calycosin Inhibit PANoptosis and Alleviate Brain Damage: A Bioinformatics and Experimental Verification Approach

PANoptosis is a newly identified form of cell death that encompasses pyroptosis, apoptosis, and necroptosis. Numerous studies have highlighted the significance of PANoptosis in brain ischemia–reperfusion (I/R) injury. Calycosin, a natural product with diverse biological activities, has demonstrated...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Huiyan An (20959966) (author)
مؤلفون آخرون:	Chongyu Shao (7361183) (author), Yu He (420536) (author), Huifen Zhou (4170631) (author), Ting Wang (16292) (author), Guanfeng Xu (5396558) (author), Jiehong Yang (9983141) (author), Haitong Wan (5559038) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Cell Biology Genetics Molecular Biology Neuroscience Physiology Pharmacology Immunology Biological Sciences not elsewhere classified reducing neuronal inflammation newly identified form exhibited favorable absorption molecular dynamics simulations improving damage caused alleviate brain damage potential mechanisms underlying neuronal death caused enhanced cell viability diverse biological activities calycosin successfully passed established molecular docking calycosin could improve ischemic stroke therapy ischemic brain injury decreased cell apoptosis calycosin inhibit panoptosis molecular docking ischemic stroke potential therapy cell death induced damage could serve cell growth biological activity stimulate ischemia significant reduction results demonstrate related targets related genes providing protection numerous studies neuroprotective role natural product key targets inhibiting panoptosis glucose deprivation encompasses pyroptosis drug similarity binding affinity bax ratio also regulated alleviating panoptosis
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Calycosin Inhibit PANoptosis and Alleviate Brain Damage: A Bioinformatics and Experimental Verification Approach

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