Rapid C–S<sup>+</sup> Bond Cleavage via 1,6-Benzyl Elimination for Traceless Modification of Bioactive Peptides

Rapid C–S<sup>+</sup> Bond Cleavage via 1,6-Benzyl Elimination for Traceless Modification of Bioactive Peptides

Peptides and proteins are invaluable therapeutics and biological tools, where stimuli-responsive and fully reversible conjugation chemistry is essential to advances in drug delivery systems and chemical biology. However, methods that allow precise conjugation, efficient regulation of biochemical fun...

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Bibliographic Details
Main Author: Yu Chai (4014536) (author)
Other Authors: Can Yu (6517646) (author), Zhi Chen (222749) (author), Wenbin Duan (21485167) (author), Huanwen Chen (1461205) (author), Xunxiang Qiu (21485170) (author), Zhengyang Xu (11447647) (author), Shengzhang Liu (16459613) (author), Anastasia Danilenko (21485173) (author), Gilles Frison (1278360) (author), Valérie Alezra (1849048) (author), Emeric Miclet (1896709) (author), Xiang Li (114679) (author), Yang Wan (323627) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Pharmacology
Inorganic Chemistry
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
weakly acidic conditions
sup >+</ sup
enhanced enzymatic stability
drug delivery systems
allow precise conjugation
stable c –
selectively alkylating met
reversibly stapled peptides
rapid c –
bioactive peptides peptides
terminal met
met ),
containing peptides
antimicrobial peptides
work describes
versatile chemistry
traceless modification
therapeutic effects
switchable conformations
reduced toxicity
peptide community
pegylated prodrugs
invaluable therapeutics
greatly benefit
first time
extracellular sites
efficient regulation
diverse applications
customized recovery
chemical biology
caged neuropeptides
bioorthogonal control
biological tools
biochemical functions
benzyl elimination
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