Outline of the computational pipeline used for designing a multi-epitope vaccine against <i>Cryptosporidium parvum.</i>

Outline of the computational pipeline used for designing a multi-epitope vaccine against <i>Cryptosporidium parvum.</i>

<p>Outline of the computational pipeline used for designing a multi-epitope vaccine against <i>Cryptosporidium parvum.</i></p>

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Guneswar Sethi (11635034) (author)
مؤلفون آخرون: Avinash Kant Lakra (22640982) (author), Kirti Nirmal (10055836) (author), Jeong Ho Hwang (7821875) (author)
منشور في: 2025
الموضوعات:
Biophysics
Biochemistry
Microbiology
Genetics
Molecular Biology
Biotechnology
Immunology
Infectious Diseases
Computational Biology
Biological Sciences not elsewhere classified
targeting immunogenic regions
enhance immune recognition
antimicrobial resistance underscore
promising vaccine candidate
ns molecular dynamics
assess construct stability
epitope subunit vaccine
tlr4 (&# 8722
tlr2 (&# 8722
dendritic cell recruitment
broad population coverage
based immunoinformatics approach
cryptosporidium parvum </
epitope vaccine
population coverage
parvum </
structural stability
selected based
molecular docking
immunoinformatics approaches
via </
silico </
xlink ">
using structural
urgent need
transmembrane domains
tlr2 agonist
three proteins
terminus using
structural modeling
padre sequence
lipoprotein lpra
inducing epitopes
improve helper
host proteins
flexibility analysis
favorable expression
experimental validation
effective vaccines
eaaak linker
diarrheal illness
cytokine release
codon optimization
cell responses
cell activation
92 %,
4 kcal
3 kcal
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