Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer

<p>Kaplan-Meier survival estimates according to the receipt of metformin. A) Overall Survival whole cohort; patients on metformin: 12.4 months (95%CI: 10.5-16.3; 100 events), patients not receiving metformin: 19.0 months (95%CI: 16.4 – 21.1; 732 events). B) Progression Free Survival whole coho...

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主要作者:	Alessio Cortellini (11023993) (author)
其他作者:	Antonio D'Alessio (16005927) (author), Siobhan Cleary (16005930) (author), Sebastiano Buti (16005933) (author), Melissa Bersanelli (16005936) (author), Paola Bordi (16005939) (author), Giuseppe Tonini (16005942) (author), Bruno Vincenzi (16005945) (author), Marco Tucci (16005948) (author), Alessandro Russo (16005951) (author), Francesco Pantano (14932554) (author), Marco Russano (16005954) (author), Luigia Stefania Stucci (16005957) (author), Maria Chiara Sergi (16005960) (author), Martina Falconi (16005963) (author), Maria Antonietta Zarzana (16005966) (author), Daniele Santini (16005969) (author), Francesco Spagnolo (16005972) (author), Enrica T. Tanda (16005975) (author), Francesca Rastelli (16005978) (author), Francesca Chiara Giorgi (16005981) (author), Federica Pergolesi (16005984) (author), Raffaele Giusti (16005987) (author), Marco Filetti (16005990) (author), Francesca Lo Bianco (16005993) (author), Paolo Marchetti (15032331) (author), Andrea Botticelli (9692501) (author), Alain Gelibter (15044460) (author), Marco Siringo (16005996) (author), Marco Ferrari (16005999) (author), Riccardo Marconcini (16006002) (author), Maria Giuseppa Vitale (16006005) (author), Linda Nicolardi (16006008) (author), Rita Chiari (16006011) (author), Michele Ghidini (16006014) (author), Olga Nigro (16006017) (author), Francesco Grossi (16006020) (author), Michele De Tursi (16006023) (author), Pietro Di Marino (16006026) (author), Paola Queirolo (15439192) (author), Sergio Bracarda (16006029) (author), Serena Macrini (16006032) (author), Alessandro Inno (15045234) (author), Federica Zoratto (16006035) (author), Enzo Veltri (16006038) (author), Chiara Spoto (16006041) (author), Maria Grazia Vitale (15223552) (author), Katia Cannita (16006044) (author), Alessandra Gennari (16006047) (author), Daniel L. Morganstein (16006050) (author), Domenico Mallardo (15022976) (author), Lorenzo Nibid (16006053) (author), Giovanna Sabarese (16006056) (author), Leonardo Brunetti (16006059) (author), Giuseppe Perrone (16006062) (author), Paolo A. Ascierto (9200743) (author), Corrado Ficorella (16006065) (author), David J. Pinato (16006068) (author)
出版:	2025
主題:	Cancer Molecular and Cellular Biology Immuno-oncology Clinical Research and Trials Methods and Technology Biostatistics Clinical-Stage Research Immunotherapy Checkpoint blockade Metabolism
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author	Alessio Cortellini (11023993)
author2	Antonio D'Alessio (16005927) Siobhan Cleary (16005930) Sebastiano Buti (16005933) Melissa Bersanelli (16005936) Paola Bordi (16005939) Giuseppe Tonini (16005942) Bruno Vincenzi (16005945) Marco Tucci (16005948) Alessandro Russo (16005951) Francesco Pantano (14932554) Marco Russano (16005954) Luigia Stefania Stucci (16005957) Maria Chiara Sergi (16005960) Martina Falconi (16005963) Maria Antonietta Zarzana (16005966) Daniele Santini (16005969) Francesco Spagnolo (16005972) Enrica T. Tanda (16005975) Francesca Rastelli (16005978) Francesca Chiara Giorgi (16005981) Federica Pergolesi (16005984) Raffaele Giusti (16005987) Marco Filetti (16005990) Francesca Lo Bianco (16005993) Paolo Marchetti (15032331) Andrea Botticelli (9692501) Alain Gelibter (15044460) Marco Siringo (16005996) Marco Ferrari (16005999) Riccardo Marconcini (16006002) Maria Giuseppa Vitale (16006005) Linda Nicolardi (16006008) Rita Chiari (16006011) Michele Ghidini (16006014) Olga Nigro (16006017) Francesco Grossi (16006020) Michele De Tursi (16006023) Pietro Di Marino (16006026) Paola Queirolo (15439192) Sergio Bracarda (16006029) Serena Macrini (16006032) Alessandro Inno (15045234) Federica Zoratto (16006035) Enzo Veltri (16006038) Chiara Spoto (16006041) Maria Grazia Vitale (15223552) Katia Cannita (16006044) Alessandra Gennari (16006047) Daniel L. Morganstein (16006050) Domenico Mallardo (15022976) Lorenzo Nibid (16006053) Giovanna Sabarese (16006056) Leonardo Brunetti (16006059) Giuseppe Perrone (16006062) Paolo A. Ascierto (9200743) Corrado Ficorella (16006065) David J. Pinato (16006068)
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
author_facet	Alessio Cortellini (11023993) Antonio D'Alessio (16005927) Siobhan Cleary (16005930) Sebastiano Buti (16005933) Melissa Bersanelli (16005936) Paola Bordi (16005939) Giuseppe Tonini (16005942) Bruno Vincenzi (16005945) Marco Tucci (16005948) Alessandro Russo (16005951) Francesco Pantano (14932554) Marco Russano (16005954) Luigia Stefania Stucci (16005957) Maria Chiara Sergi (16005960) Martina Falconi (16005963) Maria Antonietta Zarzana (16005966) Daniele Santini (16005969) Francesco Spagnolo (16005972) Enrica T. Tanda (16005975) Francesca Rastelli (16005978) Francesca Chiara Giorgi (16005981) Federica Pergolesi (16005984) Raffaele Giusti (16005987) Marco Filetti (16005990) Francesca Lo Bianco (16005993) Paolo Marchetti (15032331) Andrea Botticelli (9692501) Alain Gelibter (15044460) Marco Siringo (16005996) Marco Ferrari (16005999) Riccardo Marconcini (16006002) Maria Giuseppa Vitale (16006005) Linda Nicolardi (16006008) Rita Chiari (16006011) Michele Ghidini (16006014) Olga Nigro (16006017) Francesco Grossi (16006020) Michele De Tursi (16006023) Pietro Di Marino (16006026) Paola Queirolo (15439192) Sergio Bracarda (16006029) Serena Macrini (16006032) Alessandro Inno (15045234) Federica Zoratto (16006035) Enzo Veltri (16006038) Chiara Spoto (16006041) Maria Grazia Vitale (15223552) Katia Cannita (16006044) Alessandra Gennari (16006047) Daniel L. Morganstein (16006050) Domenico Mallardo (15022976) Lorenzo Nibid (16006053) Giovanna Sabarese (16006056) Leonardo Brunetti (16006059) Giuseppe Perrone (16006062) Paolo A. Ascierto (9200743) Corrado Ficorella (16006065) David J. Pinato (16006068)
author_role	author
dc.creator.none.fl_str_mv	Alessio Cortellini (11023993) Antonio D'Alessio (16005927) Siobhan Cleary (16005930) Sebastiano Buti (16005933) Melissa Bersanelli (16005936) Paola Bordi (16005939) Giuseppe Tonini (16005942) Bruno Vincenzi (16005945) Marco Tucci (16005948) Alessandro Russo (16005951) Francesco Pantano (14932554) Marco Russano (16005954) Luigia Stefania Stucci (16005957) Maria Chiara Sergi (16005960) Martina Falconi (16005963) Maria Antonietta Zarzana (16005966) Daniele Santini (16005969) Francesco Spagnolo (16005972) Enrica T. Tanda (16005975) Francesca Rastelli (16005978) Francesca Chiara Giorgi (16005981) Federica Pergolesi (16005984) Raffaele Giusti (16005987) Marco Filetti (16005990) Francesca Lo Bianco (16005993) Paolo Marchetti (15032331) Andrea Botticelli (9692501) Alain Gelibter (15044460) Marco Siringo (16005996) Marco Ferrari (16005999) Riccardo Marconcini (16006002) Maria Giuseppa Vitale (16006005) Linda Nicolardi (16006008) Rita Chiari (16006011) Michele Ghidini (16006014) Olga Nigro (16006017) Francesco Grossi (16006020) Michele De Tursi (16006023) Pietro Di Marino (16006026) Paola Queirolo (15439192) Sergio Bracarda (16006029) Serena Macrini (16006032) Alessandro Inno (15045234) Federica Zoratto (16006035) Enzo Veltri (16006038) Chiara Spoto (16006041) Maria Grazia Vitale (15223552) Katia Cannita (16006044) Alessandra Gennari (16006047) Daniel L. Morganstein (16006050) Domenico Mallardo (15022976) Lorenzo Nibid (16006053) Giovanna Sabarese (16006056) Leonardo Brunetti (16006059) Giuseppe Perrone (16006062) Paolo A. Ascierto (9200743) Corrado Ficorella (16006065) David J. Pinato (16006068)
dc.date.none.fl_str_mv	2025-11-25T13:21:25Z
dc.identifier.none.fl_str_mv	10.1158/1078-0432.30708391
dc.relation.none.fl_str_mv	https://figshare.com/articles/figure/Supplementary_Figure_S3_from_Type_2_Diabetes_Mellitus_and_Efficacy_Outcomes_from_Immune_Checkpoint_Blockade_in_Patients_with_Cancer/30708391
dc.rights.none.fl_str_mv	CC BY info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Cancer Molecular and Cellular Biology Immuno-oncology Clinical Research and Trials Methods and Technology Biostatistics Clinical-Stage Research Immunotherapy Checkpoint blockade Metabolism
dc.title.none.fl_str_mv	Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer
dc.type.none.fl_str_mv	Image Figure info:eu-repo/semantics/publishedVersion image
description	<p>Kaplan-Meier survival estimates according to the receipt of metformin. A) Overall Survival whole cohort; patients on metformin: 12.4 months (95%CI: 10.5-16.3; 100 events), patients not receiving metformin: 19.0 months (95%CI: 16.4 – 21.1; 732 events). B) Progression Free Survival whole cohort; patients on metformin: 7.9 months (95%CI: 5.3-10.1; 124 events), patients not receiving metformin: 8.3 months (95%CI: 7.3 – 9.5; 933 events).</p>
eu_rights_str_mv	openAccess
id	Manara_b50f97a43abb027ad3b231335a5967a1
identifier_str_mv	10.1158/1078-0432.30708391
network_acronym_str	Manara
network_name_str	ManaraRepo
oai_identifier_str	oai:figshare.com:article/30708391
publishDate	2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv	CC BY
spelling	Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with CancerAlessio Cortellini (11023993)Antonio D'Alessio (16005927)Siobhan Cleary (16005930)Sebastiano Buti (16005933)Melissa Bersanelli (16005936)Paola Bordi (16005939)Giuseppe Tonini (16005942)Bruno Vincenzi (16005945)Marco Tucci (16005948)Alessandro Russo (16005951)Francesco Pantano (14932554)Marco Russano (16005954)Luigia Stefania Stucci (16005957)Maria Chiara Sergi (16005960)Martina Falconi (16005963)Maria Antonietta Zarzana (16005966)Daniele Santini (16005969)Francesco Spagnolo (16005972)Enrica T. Tanda (16005975)Francesca Rastelli (16005978)Francesca Chiara Giorgi (16005981)Federica Pergolesi (16005984)Raffaele Giusti (16005987)Marco Filetti (16005990)Francesca Lo Bianco (16005993)Paolo Marchetti (15032331)Andrea Botticelli (9692501)Alain Gelibter (15044460)Marco Siringo (16005996)Marco Ferrari (16005999)Riccardo Marconcini (16006002)Maria Giuseppa Vitale (16006005)Linda Nicolardi (16006008)Rita Chiari (16006011)Michele Ghidini (16006014)Olga Nigro (16006017)Francesco Grossi (16006020)Michele De Tursi (16006023)Pietro Di Marino (16006026)Paola Queirolo (15439192)Sergio Bracarda (16006029)Serena Macrini (16006032)Alessandro Inno (15045234)Federica Zoratto (16006035)Enzo Veltri (16006038)Chiara Spoto (16006041)Maria Grazia Vitale (15223552)Katia Cannita (16006044)Alessandra Gennari (16006047)Daniel L. Morganstein (16006050)Domenico Mallardo (15022976)Lorenzo Nibid (16006053)Giovanna Sabarese (16006056)Leonardo Brunetti (16006059)Giuseppe Perrone (16006062)Paolo A. Ascierto (9200743)Corrado Ficorella (16006065)David J. Pinato (16006068)CancerMolecular and Cellular BiologyImmuno-oncologyClinical Research and TrialsMethods and TechnologyBiostatisticsClinical-Stage ResearchImmunotherapyCheckpoint blockadeMetabolism<p>Kaplan-Meier survival estimates according to the receipt of metformin. A) Overall Survival whole cohort; patients on metformin: 12.4 months (95%CI: 10.5-16.3; 100 events), patients not receiving metformin: 19.0 months (95%CI: 16.4 – 21.1; 732 events). B) Progression Free Survival whole cohort; patients on metformin: 7.9 months (95%CI: 5.3-10.1; 124 events), patients not receiving metformin: 8.3 months (95%CI: 7.3 – 9.5; 933 events).</p>2025-11-25T13:21:25ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/1078-0432.30708391https://figshare.com/articles/figure/Supplementary_Figure_S3_from_Type_2_Diabetes_Mellitus_and_Efficacy_Outcomes_from_Immune_Checkpoint_Blockade_in_Patients_with_Cancer/30708391CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307083912025-11-25T13:21:25Z
spellingShingle	Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer Alessio Cortellini (11023993) Cancer Molecular and Cellular Biology Immuno-oncology Clinical Research and Trials Methods and Technology Biostatistics Clinical-Stage Research Immunotherapy Checkpoint blockade Metabolism
status_str	publishedVersion
title	Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer
title_full	Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer
title_fullStr	Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer
title_full_unstemmed	Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer
title_short	Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer
title_sort	Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer
topic	Cancer Molecular and Cellular Biology Immuno-oncology Clinical Research and Trials Methods and Technology Biostatistics Clinical-Stage Research Immunotherapy Checkpoint blockade Metabolism

Supplementary Figure S3 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer

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