Diversity-Oriented Synthesis toward the Discovery of Ferrocenophane-Appended GPX4 Inhibitors as Potent Ferroptosis Inducers with Drug Likeness

Novel drug-like ferroptosis inducers with distinct chemotypes and enhanced potency are needed to overcome cancer therapy resistance. In this study, we reported a new series of ferrocenophane-appended GPX4 inhibitors as highly effective ferroptosis-inducing anticancer agents by leveraging the “one-st...

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Bibliographic Details
Main Author:	Jing Wang (6206297) (author)
Other Authors:	Zhaohu Deng (21770482) (author), Xiaocun Li (21770485) (author), Xiaomin Zhang (136250) (author), Xuejing Fan (8333463) (author), Yong Wang (12837) (author)
Published:	2025
Subjects:	Medicine Cell Biology Molecular Biology Pharmacology Biotechnology Cancer Biological Sciences not elsewhere classified work could pave mechanistic studies revealed inducing anticancer agents diverse spatial configurations demonstrating remarkable cytotoxicity cancer cells versus birds ” strategy appended gpx4 inhibitors 3d spheroid models superior ferroptosis selectivity potent ferroptosis inducers highly effective ferroptosis like ferroptosis inducers oriented synthesis toward fc </ b oriented synthesis driving ferroptosis like properties ansa </ “ one therapeutic agent standout candidate new series multiple diseases intractable cancers generating capability first time favorable drug enhanced potency dual functionality distinct chemotypes cellular levels bridged ferrocenes based chemotypes >< b >- ferrocenes
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Diversity-Oriented Synthesis toward the Discovery of Ferrocenophane-Appended GPX4 Inhibitors as Potent Ferroptosis Inducers with Drug Likeness

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