Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism
<p>Representative metabolite concentration maps from the central slice derived from a series of dynamic 3D <sup>2</sup>H CSI images summed over the first 30 minutes of signal acquisition following [2,3-<sup>2</sup>H<sub>2</sub>]fumarate injection into A11 (&...
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| _version_ | 1849927639757750272 |
|---|---|
| author | Friederike Hesse (14958870) |
| author2 | Alan J. Wright (14931815) Vencel Somai (14958873) Flaviu Bulat (14958876) Felix Kreis (14931818) Kevin M. Brindle (9752021) |
| author2_role | author author author author author |
| author_facet | Friederike Hesse (14958870) Alan J. Wright (14931815) Vencel Somai (14958873) Flaviu Bulat (14958876) Felix Kreis (14931818) Kevin M. Brindle (9752021) |
| author_role | author |
| dc.creator.none.fl_str_mv | Friederike Hesse (14958870) Alan J. Wright (14931815) Vencel Somai (14958873) Flaviu Bulat (14958876) Felix Kreis (14931818) Kevin M. Brindle (9752021) |
| dc.date.none.fl_str_mv | 2025-11-24T22:42:22Z |
| dc.identifier.none.fl_str_mv | 10.1158/0008-5472.30699281 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Figure_3_from_Imaging_Glioblastoma_Response_to_Radiotherapy_Using_sup_2_sup_H_Magnetic_Resonance_Spectroscopy_Measurements_of_Fumarate_Metabolism/30699281 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Methods and Technology Imaging Imaging probes Magnetic resonance imaging (MRI) Small animal imaging |
| dc.title.none.fl_str_mv | Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Representative metabolite concentration maps from the central slice derived from a series of dynamic 3D <sup>2</sup>H CSI images summed over the first 30 minutes of signal acquisition following [2,3-<sup>2</sup>H<sub>2</sub>]fumarate injection into A11 (<b>B</b>, <b>C</b>, <b>E</b>, and <b>F</b>), S2 (<b>H</b>, <b>I</b>, <b>K</b>, and <b>L</b>), and U87 (<b>N</b>, <b>O</b>, <b>Q</b>, and <b>P</b>) tumor-bearing mice. The color code represents concentration (in mmol/L) derived from the ratios of the peak intensities in the malate and fumarate maps to peak intensities in an initial HDO map and corrected for the number of <sup>2</sup>H labels per molecule and for signal saturation. The locations of the tumors are indicated by dotted white lines determined from an underlying T<sub>2</sub>-weighted <sup>1</sup>H image acquired concurrently using a <sup>1</sup>H volume coil. The corresponding T<sub>2</sub>-weighted <sup>1</sup>H images were acquired separately at 9.4 T. The tumor locations are outlined with dotted black lines. T<sub>2</sub>-weighted <sup>1</sup>H images (<b>A</b>, <b>G</b>, and <b>M</b>) and the fumarate (<b>B</b>, <b>H</b>, and <b>N</b>) and malate (<b>C</b>, <b>I</b>, and <b>O</b>) concentration maps pretreatment and the corresponding T<sub>2</sub>-weighted <sup>1</sup>H images (<b>D</b>, <b>J</b>, and <b>P</b>) and the fumarate (<b>E</b>, <b>K</b>, and <b>Q</b>) and malate (<b>F</b>, <b>L</b>, and <b>R</b>) concentration maps 48 hours following the last chemoradiotherapy treatment.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_b5b1f2cd1702eb2d4cf6054b8050ff2e |
| identifier_str_mv | 10.1158/0008-5472.30699281 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30699281 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate MetabolismFriederike Hesse (14958870)Alan J. Wright (14931815)Vencel Somai (14958873)Flaviu Bulat (14958876)Felix Kreis (14931818)Kevin M. Brindle (9752021)CancerMethods and TechnologyImagingImaging probesMagnetic resonance imaging (MRI)Small animal imaging<p>Representative metabolite concentration maps from the central slice derived from a series of dynamic 3D <sup>2</sup>H CSI images summed over the first 30 minutes of signal acquisition following [2,3-<sup>2</sup>H<sub>2</sub>]fumarate injection into A11 (<b>B</b>, <b>C</b>, <b>E</b>, and <b>F</b>), S2 (<b>H</b>, <b>I</b>, <b>K</b>, and <b>L</b>), and U87 (<b>N</b>, <b>O</b>, <b>Q</b>, and <b>P</b>) tumor-bearing mice. The color code represents concentration (in mmol/L) derived from the ratios of the peak intensities in the malate and fumarate maps to peak intensities in an initial HDO map and corrected for the number of <sup>2</sup>H labels per molecule and for signal saturation. The locations of the tumors are indicated by dotted white lines determined from an underlying T<sub>2</sub>-weighted <sup>1</sup>H image acquired concurrently using a <sup>1</sup>H volume coil. The corresponding T<sub>2</sub>-weighted <sup>1</sup>H images were acquired separately at 9.4 T. The tumor locations are outlined with dotted black lines. T<sub>2</sub>-weighted <sup>1</sup>H images (<b>A</b>, <b>G</b>, and <b>M</b>) and the fumarate (<b>B</b>, <b>H</b>, and <b>N</b>) and malate (<b>C</b>, <b>I</b>, and <b>O</b>) concentration maps pretreatment and the corresponding T<sub>2</sub>-weighted <sup>1</sup>H images (<b>D</b>, <b>J</b>, and <b>P</b>) and the fumarate (<b>E</b>, <b>K</b>, and <b>Q</b>) and malate (<b>F</b>, <b>L</b>, and <b>R</b>) concentration maps 48 hours following the last chemoradiotherapy treatment.</p>2025-11-24T22:42:22ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/0008-5472.30699281https://figshare.com/articles/figure/Figure_3_from_Imaging_Glioblastoma_Response_to_Radiotherapy_Using_sup_2_sup_H_Magnetic_Resonance_Spectroscopy_Measurements_of_Fumarate_Metabolism/30699281CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/306992812025-11-24T22:42:22Z |
| spellingShingle | Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism Friederike Hesse (14958870) Cancer Methods and Technology Imaging Imaging probes Magnetic resonance imaging (MRI) Small animal imaging |
| status_str | publishedVersion |
| title | Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| title_full | Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| title_fullStr | Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| title_full_unstemmed | Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| title_short | Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| title_sort | Figure 3 from Imaging Glioblastoma Response to Radiotherapy Using <sup>2</sup>H Magnetic Resonance Spectroscopy Measurements of Fumarate Metabolism |
| topic | Cancer Methods and Technology Imaging Imaging probes Magnetic resonance imaging (MRI) Small animal imaging |