Discovery of Ruthenium(Arene) Metalloantibiotics: Advancing Selective and Potent Therapeutics against Gram-Negative Acinetobacter baumannii

No new class of antibiotics active against Acinetobacter baumanniia critical WHO priority pathogen (2024)has reached clinical use in over 50 years. To address this, we designed, synthesized, and characterized a novel library of ruthenium arene complexes and screened them against various bacterial...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Kajal Chaudhary (21271120) (author)
مؤلفون آخرون:	Bhumika Agrahari (21271123) (author), Himanshu Sonker (18057432) (author), Sayari Dewan (21271126) (author), Ritika Gautam Singh (18057438) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Microbiology Pharmacology Biotechnology Immunology Cancer Infectious Diseases Space Science Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified various bacterial strains reached clinical use potent lead compound negative acinetobacter baumannii acinetobacter baumannii  20 × mic ruthenium arene complexes potent therapeutics 20 passages therapeutic efficacy selective activity resistance emerging promising foundation priority pathogen novel library new class generation broad associated bacteria antibiotics active advancing selective achieving 78 50 years 5 μg 4 μg 2024 )
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Discovery of Ruthenium(Arene) Metalloantibiotics: Advancing Selective and Potent Therapeutics against Gram-Negative Acinetobacter baumannii

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