<sup>18</sup>F‑/<sup>68</sup>Ga-Labeled Peptide-Based Probes for PET Imaging of ROR1 Expression

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is highly upregulated in multiple cancers and serves as a promising biomarker for patient staging and therapy guidance. We designed five ROR1-targeted radiotracers, including linear and cyclic peptides derived from PR7, and evaluated their speci...

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Hlavní autor:	Tao Yang (184280) (author)
Další autoři:	Jiahui Sun (4985156) (author), Guolong Huang (13729357) (author), Hong Wang (13528) (author), Zhexin He (22797518) (author), Siying Lin (5698055) (author), Yanjie Wang (444557) (author), Rongqiang Zhuang (1923625) (author), Xianzhong Zhang (1424671) (author), Hongwu Liu (1592272) (author), Zhide Guo (1424674) (author)
Vydáno:	2025
Témata:	Biochemistry Medicine Cell Biology Pharmacology Biotechnology Immunology Cancer Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified transcriptomic analysis indicated saturation binding assays renal clearance observed f ] alf cyclic peptides derived blocking studies confirmed personalized cancer therapy f ‑/< sup 68 </ sup 18 </ sup quantitative ror1 visualization designed five ror1 ga ] ga therapy guidance [< sup targeted radiotracers promising biomarker probes showed potential involvement pet imaging patient staging multiple cancers mc38 models labeled peptide including linear highly upregulated favorable target based probes akt pathway
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<sup>18</sup>F‑/<sup>68</sup>Ga-Labeled Peptide-Based Probes for PET Imaging of ROR1 Expression

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