Broad-spectrum profiling of plasma miRNA at early (D1) and late stage of latency (D7).

Broad-spectrum profiling of plasma miRNA at early (D1) and late stage of latency (D7).

<p>(A) Multi-block sPLS-DA scatter plots, with miR block = plasma miRNA expression levels; macro block = cutaneous perfusion, TEWL, CRP, and CBC levels at D1 post-irradiation. (B) Multi-scale correlations between miRNA expression levels and clinical, functional, and biological analyses are ill...

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Bibliographic Details
Main Author: Lucie Ancel (22022065) (author)
Other Authors: Jules Gueguen (22022068) (author), Guillaume Thoër (22022071) (author), Jules Marçais (22022074) (author), Aïda Chemloul (22022077) (author), Bernard Le Guen (10896352) (author), Marc Benderitter (168382) (author), Radia Tamarat (5965670) (author), Maâmar Souidi (6815306) (author), Mohamed Amine Benadjaoud (4172245) (author), Stéphane Flamant (14912708) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Cell Biology
Genetics
Molecular Biology
Neuroscience
Biotechnology
Immunology
Developmental Biology
Cancer
Biological Sciences not elsewhere classified
Physical Sciences not elsewhere classified
symptom onset ranging
refine mirna signatures
prognostic mirna signatures
clinical symptoms appear
based biomarker signatures
two latency stages
identified candidate mirnas
da ), signatures
localized radiation injury
mice </ p
localized radiation injuries
day 14 clinical
early lri diagnosis
lri severity prognosis
mirnas ),
localized injuries
early diagnosis
lri severity
unrelated mice
radiation response
radiation exposure
latency phase
tissue injuries
day 7
day 1
diagnosing lri
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used throughout
treatment outcomes
tissue necrosis
tissue damage
severe outcomes
previously associated
presymptomatic microrna
powerful tool
performed broad
mouse model
irradiation ).
hindlimb irradiation
functional outcomes
effective triage
dose groups
different severities
adapted treatment
7 post
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Description
Summary:<p>(A) Multi-block sPLS-DA scatter plots, with miR block = plasma miRNA expression levels; macro block = cutaneous perfusion, TEWL, CRP, and CBC levels at D1 post-irradiation. (B) Multi-scale correlations between miRNA expression levels and clinical, functional, and biological analyses are illustrated in a circle plot, with positive correlations represented in orange and negative correlations in black, with a cut-off of 0.5. Expression of each parameter as a function of irradiation group is represented with external lines. Control group: n = 10; 20 Gy: n = 9; 40 Gy: n = 10; 80 Gy: n = 10. (C) Multi-block sPLS-DA scatter plots, with miR block = plasma miRNA expression levels; macro block = injury score, cutaneous perfusion, TEWL, CRP, and CBC levels at D7 post-irradiation. (D) Multi-scale correlations between miRNA expression levels and clinical, functional, and biological analyses are illustrated in a circle plot with a cut-off of 0.5. Control group: n = 10; 20 Gy: n = 9; 40 Gy: n = 9; 80 Gy: n = 10.</p>

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