Samples & cell type composition in sc/snRNA-seq.

Samples & cell type composition in sc/snRNA-seq.

<div><p>Melanoma brain metastasis (MBM) remains lethal with limited treatment efficacy. Meanwhile, the cellular origins and drivers of brain metastasis from melanoma have yet to be defined. Through integrated single-cell/single-nucleus RNA sequencing of 26 melanoma samples, we identified...

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Príomhchruthaitheoir:	Jingxin Zeng (18773484) (author)
Rannpháirtithe:	Ling Lin (57361) (author), Yangyang Ma (6329852) (author), Wenzhe Huang (446343) (author), Quan Luo (1423180) (author), Ju Wen (14784239) (author)
Foilsithe / Cruthaithe:	2025
Ábhair:	Cell Biology Genetics Neuroscience Biotechnology Immunology Developmental Biology Cancer Hematology Virology Biological Sciences not elsewhere classified Information Systems not elsewhere classified limited treatment efficacy associated tumor cells adhesion genes (< nucleus rna sequencing metastatic tumor subpopulation 26 melanoma samples study identifies mbmatcs mbm ecosystems showed div >< p melanoma brain metastasis metastatic pathways bulk rna brain metastasis melanoma patients validation cohorts upregulated neural treg enrichment remains lethal potential activity nrg3 </ ncam1 </ mela3 ). lag3 </ high risk havcr2 </ early stratification clinical relevance cellular origins cellular origin brain tropism >), suggesting 1 </
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Míreanna comhchosúla

scRNA-seq and snRNA-seq profiling of 26 melanoma samples.
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Marker genes in melanoma tumor cells across PT, ECM and MBM by sc/snRNA-seq.
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Single cell RNA-seq and snRNA-seq profiling of the PTs (primary melanoma), ECMs (extracranial melanoma metastases) and MBMs (melanoma brain metastases) environments.
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The MBM-Index as an independent predictor of overall survival (OS) in melanoma.
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Identification of melanoma brain metastasis-associated tumor cell subpopulations (MBMATCs).
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Tumor cell-specific transcriptomic features across PTs, ECMs and MBMs.
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Immune landscape and CD8<sup>+</sup> T cell transition states in PTs, ECMs and MBMs.
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Samples & cell type composition in melanoma tumor cells.
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AXL and MITF signature genes.
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Identification of therapeutic drugs with high drug sensitivity for brain metastasis-associated tumor cells (MBMATCs) and high-brain metastasis (MBM) index patients.
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The enriched pathway by all transcripts differentially expressed between MBMATCs and other tumor cells, and between MBM-High and MBM-Low groups.
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The MBM-Index showed no significant correlation with clinicopathological features.
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Interaction between MBMATCs and the immune microenvironment.
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Pseudotime trajectory analysis of melanoma clusters Mela4 and Mela5.
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Immune cells profiling in PTs, ECMs and MBMs.
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