Samples & cell type composition in sc/snRNA-seq.

Samples & cell type composition in sc/snRNA-seq.

<div><p>Melanoma brain metastasis (MBM) remains lethal with limited treatment efficacy. Meanwhile, the cellular origins and drivers of brain metastasis from melanoma have yet to be defined. Through integrated single-cell/single-nucleus RNA sequencing of 26 melanoma samples, we identified...

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Detalles Bibliográficos
Autor Principal: Jingxin Zeng (18773484) (author)
Outros autores: Ling Lin (57361) (author), Yangyang Ma (6329852) (author), Wenzhe Huang (446343) (author), Quan Luo (1423180) (author), Ju Wen (14784239) (author)
Publicado: 2025
Subjects:
Cell Biology
Genetics
Neuroscience
Biotechnology
Immunology
Developmental Biology
Cancer
Hematology
Virology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
limited treatment efficacy
associated tumor cells
adhesion genes (<
nucleus rna sequencing
metastatic tumor subpopulation
26 melanoma samples
study identifies mbmatcs
mbm ecosystems showed
div >< p
melanoma brain metastasis
metastatic pathways
bulk rna
brain metastasis
melanoma patients
validation cohorts
upregulated neural
treg enrichment
remains lethal
potential activity
nrg3 </
ncam1 </
mela3 ).
lag3 </
high risk
havcr2 </
early stratification
clinical relevance
cellular origins
cellular origin
brain tropism
>), suggesting
1 </
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