DataSheet1_A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.PDF
<p>Fracture healing is a complex process which sometimes results in non-unions, leading to prolonged disability and high morbidity. Traditional methods of optimising fracture treatments, such as in vitro benchtop testing and in vivo randomised controlled trials, face limitations, particularly...
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2024
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| _version_ | 1852025864173125632 |
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| author | George T. Morgan (19867125) |
| author2 | Lucas Low (19867128) Arul Ramasamy (9381941) Spyros D. Masouros (8218815) |
| author2_role | author author author |
| author_facet | George T. Morgan (19867125) Lucas Low (19867128) Arul Ramasamy (9381941) Spyros D. Masouros (8218815) |
| author_role | author |
| dc.creator.none.fl_str_mv | George T. Morgan (19867125) Lucas Low (19867128) Arul Ramasamy (9381941) Spyros D. Masouros (8218815) |
| dc.date.none.fl_str_mv | 2024-10-18T04:11:06Z |
| dc.identifier.none.fl_str_mv | 10.3389/fbioe.2024.1477405.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/DataSheet1_A_novel_strain-based_bone-fracture_healing_algorithm_is_able_to_predict_a_range_of_healing_outcomes_PDF/27253776 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biotechnology Biological Engineering Genetic Engineering Biomarkers Biomaterials Biomechanical Engineering Biomedical Engineering not elsewhere classified Synthetic Biology Agricultural Marine Biotechnology Bioremediation Bioprocessing, Bioproduction and Bioproducts Industrial Biotechnology Diagnostics (incl. Biosensors) Industrial Microbiology (incl. Biofeedstocks) Industrial Molecular Engineering of Nucleic Acids and Proteins Industrial Biotechnology not elsewhere classified Medical Biotechnology Diagnostics (incl. Biosensors) Medical Molecular Engineering of Nucleic Acids and Proteins Regenerative Medicine (incl. Stem Cells and Tissue Engineering) Medical Biotechnology not elsewhere classified fracture healing algorithm bone principal strains fracture fixation in silico trial healing assessment non-union |
| dc.title.none.fl_str_mv | DataSheet1_A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.PDF |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p>Fracture healing is a complex process which sometimes results in non-unions, leading to prolonged disability and high morbidity. Traditional methods of optimising fracture treatments, such as in vitro benchtop testing and in vivo randomised controlled trials, face limitations, particularly in evaluating the entire healing process. This study introduces a novel, strain-based fracture-healing algorithm designed to predict a wide range of healing outcomes, including both successful unions and non-unions. The algorithm uses principal strains as mechanical stimuli to simulate fracture healing in response to local mechanical environments within the callus region. The model demonstrates good agreement with experimental data from ovine metatarsal osteotomies across six fracture cases with varying gap widths and inter-fragmentary strains, replicates physiological bony growth patterns, and is independent of the initial callus geometry. This computational approach provides a framework for developing new fracture-fixation devices, aid in pre-surgical planning, and optimise rehabilitation strategies.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_bb78055fdc0a4d77cc14fbfc6e3dfd6f |
| identifier_str_mv | 10.3389/fbioe.2024.1477405.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/27253776 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | DataSheet1_A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.PDFGeorge T. Morgan (19867125)Lucas Low (19867128)Arul Ramasamy (9381941)Spyros D. Masouros (8218815)BiotechnologyBiological EngineeringGenetic EngineeringBiomarkersBiomaterialsBiomechanical EngineeringBiomedical Engineering not elsewhere classifiedSynthetic BiologyAgricultural Marine BiotechnologyBioremediationBioprocessing, Bioproduction and BioproductsIndustrial Biotechnology Diagnostics (incl. Biosensors)Industrial Microbiology (incl. Biofeedstocks)Industrial Molecular Engineering of Nucleic Acids and ProteinsIndustrial Biotechnology not elsewhere classifiedMedical Biotechnology Diagnostics (incl. Biosensors)Medical Molecular Engineering of Nucleic Acids and ProteinsRegenerative Medicine (incl. Stem Cells and Tissue Engineering)Medical Biotechnology not elsewhere classifiedfracture healing algorithmboneprincipal strainsfracture fixationin silico trialhealing assessmentnon-union<p>Fracture healing is a complex process which sometimes results in non-unions, leading to prolonged disability and high morbidity. Traditional methods of optimising fracture treatments, such as in vitro benchtop testing and in vivo randomised controlled trials, face limitations, particularly in evaluating the entire healing process. This study introduces a novel, strain-based fracture-healing algorithm designed to predict a wide range of healing outcomes, including both successful unions and non-unions. The algorithm uses principal strains as mechanical stimuli to simulate fracture healing in response to local mechanical environments within the callus region. The model demonstrates good agreement with experimental data from ovine metatarsal osteotomies across six fracture cases with varying gap widths and inter-fragmentary strains, replicates physiological bony growth patterns, and is independent of the initial callus geometry. This computational approach provides a framework for developing new fracture-fixation devices, aid in pre-surgical planning, and optimise rehabilitation strategies.</p>2024-10-18T04:11:06ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fbioe.2024.1477405.s001https://figshare.com/articles/dataset/DataSheet1_A_novel_strain-based_bone-fracture_healing_algorithm_is_able_to_predict_a_range_of_healing_outcomes_PDF/27253776CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/272537762024-10-18T04:11:06Z |
| spellingShingle | DataSheet1_A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.PDF George T. Morgan (19867125) Biotechnology Biological Engineering Genetic Engineering Biomarkers Biomaterials Biomechanical Engineering Biomedical Engineering not elsewhere classified Synthetic Biology Agricultural Marine Biotechnology Bioremediation Bioprocessing, Bioproduction and Bioproducts Industrial Biotechnology Diagnostics (incl. Biosensors) Industrial Microbiology (incl. Biofeedstocks) Industrial Molecular Engineering of Nucleic Acids and Proteins Industrial Biotechnology not elsewhere classified Medical Biotechnology Diagnostics (incl. Biosensors) Medical Molecular Engineering of Nucleic Acids and Proteins Regenerative Medicine (incl. Stem Cells and Tissue Engineering) Medical Biotechnology not elsewhere classified fracture healing algorithm bone principal strains fracture fixation in silico trial healing assessment non-union |
| status_str | publishedVersion |
| title | DataSheet1_A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.PDF |
| title_full | DataSheet1_A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.PDF |
| title_fullStr | DataSheet1_A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.PDF |
| title_full_unstemmed | DataSheet1_A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.PDF |
| title_short | DataSheet1_A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.PDF |
| title_sort | DataSheet1_A novel strain-based bone-fracture healing algorithm is able to predict a range of healing outcomes.PDF |
| topic | Biotechnology Biological Engineering Genetic Engineering Biomarkers Biomaterials Biomechanical Engineering Biomedical Engineering not elsewhere classified Synthetic Biology Agricultural Marine Biotechnology Bioremediation Bioprocessing, Bioproduction and Bioproducts Industrial Biotechnology Diagnostics (incl. Biosensors) Industrial Microbiology (incl. Biofeedstocks) Industrial Molecular Engineering of Nucleic Acids and Proteins Industrial Biotechnology not elsewhere classified Medical Biotechnology Diagnostics (incl. Biosensors) Medical Molecular Engineering of Nucleic Acids and Proteins Regenerative Medicine (incl. Stem Cells and Tissue Engineering) Medical Biotechnology not elsewhere classified fracture healing algorithm bone principal strains fracture fixation in silico trial healing assessment non-union |