Cinacalcet administered before the inactive phase upregulate pathways of energy metabolism.

The transcriptomes of parathyroid glands from Cinacalcet treated CKD groups Cina1 (N = 7) and Cina2 (N = 10) were compared to glands from untreated CKD rats investigated at similar time points: PNX1 (N = 6) and PNX2...

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Main Author:	Søren Egstrand (10906087) (author)
Other Authors:	Maria Lerche Mace (4740072) (author), Marya Morevati (5593805) (author), Lars Henning Engelholm (20513519) (author), Jesper Skovhus Thomsen (9466715) (author), Annemarie Brüel (9544646) (author), Klaus Olgaard (4740075) (author), Ewa Lewin (4740081) (author)
Published:	2025
Subjects:	Medicine Cell Biology Neuroscience Physiology Pharmacology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified transcriptomic analysis showed sup >+</ sup increased adaptive response current treatment based untreated uremic group significant clinical complication hyperplastic parathyroid glands tca cycle </ oxidative phosphorylation </ div >< p 37 %, p 92 ± 0 46 ± 0 cinacalcet drug target significantly reduce ki parathyroid gland proliferation parathyroid cell proliferation without cinacalcet treatment chronotherapy treatment (< 67 index compared parathyroid proliferation cinacalcet treatment cinacalcet (< treatment early significant increase reduced proliferation parathyroid hyperplasia parathyroid calcium cina2 </ cina1 </ >: 0 untreated rats using chronotherapy using calcimimetics upregulated pathways striking effect sensing receptor secondary hyperparathyroidism present study possible benefit mitotic activity markedly impacted inhibitory effect genes involved energy metabolism ckd leading cells compared cardiovascular disease bone abnormalities active phase >, encoding 09 ). 006 ). 001 ). 0001 ).
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Cinacalcet administered before the inactive phase upregulate pathways of energy metabolism.

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