Bifunctional Inhibition of Botulinum Neurotoxin A Protease: Unexpected Active Site Inhibition Enhances Covalent Targeting of an Allosteric Site

Botulinum neurotoxin (BoNT) is the most toxic protein known to man and a Tier 1 bioterrorism agent. Among its serotypes, BoNT/A possesses the greatest potency and persistence, as such strategies to counteract it are highly coveted. Bifunctional molecules incorporating both metal chelation and a cova...

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Bibliographic Details
Main Author:	Mingliang Lin (3745552) (author)
Other Authors:	Nishant Karadkhelkar (21083917) (author), Yanjie Li (1463440) (author), Lisa M. Eubanks (1371738) (author), William H. Tepp (226108) (author), Sabine Pellett (528430) (author), Kim D. Janda (163029) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Microbiology Molecular Biology Neuroscience Pharmacology Biotechnology Cancer Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified toxic protein known shown great potential bifunctional molecules incorporating bifunctional inhibition zinc metal vivo </ thus future small molecule reconnaissance studies new warheads metal chelation kinetic analyses inhibitors challenged highly coveted greatest potency enzyme pocket covalent warhead chelating scaffolds botulinum neurotoxin
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Bifunctional Inhibition of Botulinum Neurotoxin A Protease: Unexpected Active Site Inhibition Enhances Covalent Targeting of an Allosteric Site

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