Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer

Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer

<p>Mechanistic link between LKB1 and PARP1. (a) A bioinformatics tool (Pepsite) was utilized to predict the possibility of PARP1 docking on the di-Arg ER retention motif of LKB1 (PRR). (b) Localization of PARP1 (green) relative to LKB1 (red) in LKB1-WT A549 cells and H1299 cells. Scale bar = 2...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Li-Li Long (14963775) (author)
Άλλοι συγγραφείς: Si-Cong Ma (14963778) (author), Ze-Qin Guo (14963781) (author), Yan-Pei Zhang (14963784) (author), Zhenzhen Fan (14963787) (author), Li-Juan Liu (14963790) (author), Li Liu (12292657) (author), Duan-Duan Han (14963793) (author), Meng-Xin Leng (14963796) (author), Jian Wang (14963799) (author), Xue-Jun Guo (14963802) (author), Jia-Le Tan (14963805) (author), Xiao-Ting Cai (14963808) (author), Yan Lin (14963811) (author), Xinghua Pan (14963814) (author), De-Hua Wu (14963817) (author), Xue Bai (14963820) (author), Zhong-Yi Dong (11855458) (author)
Έκδοση: 2025
Θέματα:
Cancer
Tumor Biology
Molecular and Cellular Biology
Immuno-oncology
DNA Damage and Repair
DNA repair
Immunotherapy
Combination immunotherapy
Lung Cancer
Tumor Microenvironment
Immune cells and the microenvironment
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Περιγραφή
Περίληψη:<p>Mechanistic link between LKB1 and PARP1. (a) A bioinformatics tool (Pepsite) was utilized to predict the possibility of PARP1 docking on the di-Arg ER retention motif of LKB1 (PRR). (b) Localization of PARP1 (green) relative to LKB1 (red) in LKB1-WT A549 cells and H1299 cells. Scale bar = 20 μm. (c) Lysates from H1299 cells were subjected to IP with anti-PARP1 and anti-LKB1 antibodies and western blot analysis with the indicated antibodies. (d) IHC statistical analysis of PAR expression in LLC-shCtrl and LLC-shLkb1 tumors. n=5 fields from independent tumors. Data are represented as mean ± SD; Student's t-tests; **, P < 0.01.</p>

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