Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
<p>Mechanistic link between LKB1 and PARP1. (a) A bioinformatics tool (Pepsite) was utilized to predict the possibility of PARP1 docking on the di-Arg ER retention motif of LKB1 (PRR). (b) Localization of PARP1 (green) relative to LKB1 (red) in LKB1-WT A549 cells and H1299 cells. Scale bar = 2...
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| Այլ հեղինակներ: | , , , , , , , , , , , , , , , , |
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2025
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Ավելացրեք ցուցիչ
Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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| _version_ | 1849927638849683456 |
|---|---|
| author | Li-Li Long (14963775) |
| author2 | Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458) |
| author2_role | author author author author author author author author author author author author author author author author author |
| author_facet | Li-Li Long (14963775) Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458) |
| author_role | author |
| dc.creator.none.fl_str_mv | Li-Li Long (14963775) Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458) |
| dc.date.none.fl_str_mv | 2025-11-24T23:01:57Z |
| dc.identifier.none.fl_str_mv | 10.1158/0008-5472.30700011 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Figure_S2_from_PARP_Inhibition_Induces_Synthetic_Lethality_and_Adaptive_Immunity_in_LKB1-Mutant_Lung_Cancer/30700011 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment |
| dc.title.none.fl_str_mv | Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Mechanistic link between LKB1 and PARP1. (a) A bioinformatics tool (Pepsite) was utilized to predict the possibility of PARP1 docking on the di-Arg ER retention motif of LKB1 (PRR). (b) Localization of PARP1 (green) relative to LKB1 (red) in LKB1-WT A549 cells and H1299 cells. Scale bar = 20 μm. (c) Lysates from H1299 cells were subjected to IP with anti-PARP1 and anti-LKB1 antibodies and western blot analysis with the indicated antibodies. (d) IHC statistical analysis of PAR expression in LLC-shCtrl and LLC-shLkb1 tumors. n=5 fields from independent tumors. Data are represented as mean ± SD; Student's t-tests; **, P < 0.01.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_bdf58645e940f4594a295bffa5351b2b |
| identifier_str_mv | 10.1158/0008-5472.30700011 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30700011 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung CancerLi-Li Long (14963775)Si-Cong Ma (14963778)Ze-Qin Guo (14963781)Yan-Pei Zhang (14963784)Zhenzhen Fan (14963787)Li-Juan Liu (14963790)Li Liu (12292657)Duan-Duan Han (14963793)Meng-Xin Leng (14963796)Jian Wang (14963799)Xue-Jun Guo (14963802)Jia-Le Tan (14963805)Xiao-Ting Cai (14963808)Yan Lin (14963811)Xinghua Pan (14963814)De-Hua Wu (14963817)Xue Bai (14963820)Zhong-Yi Dong (11855458)CancerTumor BiologyMolecular and Cellular BiologyImmuno-oncologyDNA Damage and RepairDNA repairImmunotherapyCombination immunotherapyLung CancerTumor MicroenvironmentImmune cells and the microenvironment<p>Mechanistic link between LKB1 and PARP1. (a) A bioinformatics tool (Pepsite) was utilized to predict the possibility of PARP1 docking on the di-Arg ER retention motif of LKB1 (PRR). (b) Localization of PARP1 (green) relative to LKB1 (red) in LKB1-WT A549 cells and H1299 cells. Scale bar = 20 μm. (c) Lysates from H1299 cells were subjected to IP with anti-PARP1 and anti-LKB1 antibodies and western blot analysis with the indicated antibodies. (d) IHC statistical analysis of PAR expression in LLC-shCtrl and LLC-shLkb1 tumors. n=5 fields from independent tumors. Data are represented as mean ± SD; Student's t-tests; **, P < 0.01.</p>2025-11-24T23:01:57ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/0008-5472.30700011https://figshare.com/articles/figure/Figure_S2_from_PARP_Inhibition_Induces_Synthetic_Lethality_and_Adaptive_Immunity_in_LKB1-Mutant_Lung_Cancer/30700011CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307000112025-11-24T23:01:57Z |
| spellingShingle | Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer Li-Li Long (14963775) Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment |
| status_str | publishedVersion |
| title | Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| title_full | Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| title_fullStr | Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| title_full_unstemmed | Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| title_short | Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| title_sort | Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer |
| topic | Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment |