Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer

<p>Mechanistic link between LKB1 and PARP1. (a) A bioinformatics tool (Pepsite) was utilized to predict the possibility of PARP1 docking on the di-Arg ER retention motif of LKB1 (PRR). (b) Localization of PARP1 (green) relative to LKB1 (red) in LKB1-WT A549 cells and H1299 cells. Scale bar = 2...

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主要作者:	Li-Li Long (14963775) (author)
其他作者:	Si-Cong Ma (14963778) (author), Ze-Qin Guo (14963781) (author), Yan-Pei Zhang (14963784) (author), Zhenzhen Fan (14963787) (author), Li-Juan Liu (14963790) (author), Li Liu (12292657) (author), Duan-Duan Han (14963793) (author), Meng-Xin Leng (14963796) (author), Jian Wang (14963799) (author), Xue-Jun Guo (14963802) (author), Jia-Le Tan (14963805) (author), Xiao-Ting Cai (14963808) (author), Yan Lin (14963811) (author), Xinghua Pan (14963814) (author), De-Hua Wu (14963817) (author), Xue Bai (14963820) (author), Zhong-Yi Dong (11855458) (author)
出版:	2025
主题:	Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment
标签:	添加标签没有标签, 成为第一个标记此记录!

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author	Li-Li Long (14963775)
author2	Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458)
author2_role	author author author author author author author author author author author author author author author author author
author_facet	Li-Li Long (14963775) Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458)
author_role	author
dc.creator.none.fl_str_mv	Li-Li Long (14963775) Si-Cong Ma (14963778) Ze-Qin Guo (14963781) Yan-Pei Zhang (14963784) Zhenzhen Fan (14963787) Li-Juan Liu (14963790) Li Liu (12292657) Duan-Duan Han (14963793) Meng-Xin Leng (14963796) Jian Wang (14963799) Xue-Jun Guo (14963802) Jia-Le Tan (14963805) Xiao-Ting Cai (14963808) Yan Lin (14963811) Xinghua Pan (14963814) De-Hua Wu (14963817) Xue Bai (14963820) Zhong-Yi Dong (11855458)
dc.date.none.fl_str_mv	2025-11-24T23:01:57Z
dc.identifier.none.fl_str_mv	10.1158/0008-5472.30700011
dc.relation.none.fl_str_mv	https://figshare.com/articles/figure/Figure_S2_from_PARP_Inhibition_Induces_Synthetic_Lethality_and_Adaptive_Immunity_in_LKB1-Mutant_Lung_Cancer/30700011
dc.rights.none.fl_str_mv	CC BY info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment
dc.title.none.fl_str_mv	Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
dc.type.none.fl_str_mv	Image Figure info:eu-repo/semantics/publishedVersion image
description	<p>Mechanistic link between LKB1 and PARP1. (a) A bioinformatics tool (Pepsite) was utilized to predict the possibility of PARP1 docking on the di-Arg ER retention motif of LKB1 (PRR). (b) Localization of PARP1 (green) relative to LKB1 (red) in LKB1-WT A549 cells and H1299 cells. Scale bar = 20 μm. (c) Lysates from H1299 cells were subjected to IP with anti-PARP1 and anti-LKB1 antibodies and western blot analysis with the indicated antibodies. (d) IHC statistical analysis of PAR expression in LLC-shCtrl and LLC-shLkb1 tumors. n=5 fields from independent tumors. Data are represented as mean ± SD; Student's t-tests; **, P < 0.01.</p>
eu_rights_str_mv	openAccess
id	Manara_bdf58645e940f4594a295bffa5351b2b
identifier_str_mv	10.1158/0008-5472.30700011
network_acronym_str	Manara
network_name_str	ManaraRepo
oai_identifier_str	oai:figshare.com:article/30700011
publishDate	2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv	CC BY
spelling	Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung CancerLi-Li Long (14963775)Si-Cong Ma (14963778)Ze-Qin Guo (14963781)Yan-Pei Zhang (14963784)Zhenzhen Fan (14963787)Li-Juan Liu (14963790)Li Liu (12292657)Duan-Duan Han (14963793)Meng-Xin Leng (14963796)Jian Wang (14963799)Xue-Jun Guo (14963802)Jia-Le Tan (14963805)Xiao-Ting Cai (14963808)Yan Lin (14963811)Xinghua Pan (14963814)De-Hua Wu (14963817)Xue Bai (14963820)Zhong-Yi Dong (11855458)CancerTumor BiologyMolecular and Cellular BiologyImmuno-oncologyDNA Damage and RepairDNA repairImmunotherapyCombination immunotherapyLung CancerTumor MicroenvironmentImmune cells and the microenvironment<p>Mechanistic link between LKB1 and PARP1. (a) A bioinformatics tool (Pepsite) was utilized to predict the possibility of PARP1 docking on the di-Arg ER retention motif of LKB1 (PRR). (b) Localization of PARP1 (green) relative to LKB1 (red) in LKB1-WT A549 cells and H1299 cells. Scale bar = 20 μm. (c) Lysates from H1299 cells were subjected to IP with anti-PARP1 and anti-LKB1 antibodies and western blot analysis with the indicated antibodies. (d) IHC statistical analysis of PAR expression in LLC-shCtrl and LLC-shLkb1 tumors. n=5 fields from independent tumors. Data are represented as mean ± SD; Student's t-tests; **, P < 0.01.</p>2025-11-24T23:01:57ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/0008-5472.30700011https://figshare.com/articles/figure/Figure_S2_from_PARP_Inhibition_Induces_Synthetic_Lethality_and_Adaptive_Immunity_in_LKB1-Mutant_Lung_Cancer/30700011CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307000112025-11-24T23:01:57Z
spellingShingle	Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer Li-Li Long (14963775) Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment
status_str	publishedVersion
title	Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
title_full	Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
title_fullStr	Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
title_full_unstemmed	Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
title_short	Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
title_sort	Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer
topic	Cancer Tumor Biology Molecular and Cellular Biology Immuno-oncology DNA Damage and Repair DNA repair Immunotherapy Combination immunotherapy Lung Cancer Tumor Microenvironment Immune cells and the microenvironment

Figure S2 from PARP Inhibition Induces Synthetic Lethality and Adaptive Immunity in LKB1-Mutant Lung Cancer

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