Image1_Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection.JPEG
Introduction<p>Osteoarthritis (OA) is regarded as one of the most prevealent irreversible joint degenerative disorder worldwide. Recently, considerable interest in utilizing intra-articular (IA) injections for managing OA has been raised.</p>Methods<p>In this study, IA injectable s...
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2024
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| author | Nouran Abdelmageed Ali (19956204) |
| author2 | Nadia M. Morsi (4099249) Shaimaa M. Badr-Eldin (12134042) Rehab N. Shamma (4862437) |
| author2_role | author author author |
| author_facet | Nouran Abdelmageed Ali (19956204) Nadia M. Morsi (4099249) Shaimaa M. Badr-Eldin (12134042) Rehab N. Shamma (4862437) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nouran Abdelmageed Ali (19956204) Nadia M. Morsi (4099249) Shaimaa M. Badr-Eldin (12134042) Rehab N. Shamma (4862437) |
| dc.date.none.fl_str_mv | 2024-10-28T04:15:53Z |
| dc.identifier.none.fl_str_mv | 10.3389/fbioe.2024.1439085.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Image1_Diacerein-loaded_surface_modified_iron_oxide_microparticles_SMIOMPs_an_emerging_magnetic_system_for_management_of_osteoarthritis_via_intra-articular_injection_JPEG/27313905 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biotechnology Biological Engineering Genetic Engineering Biomarkers Biomaterials Biomechanical Engineering Biomedical Engineering not elsewhere classified Synthetic Biology Agricultural Marine Biotechnology Bioremediation Bioprocessing, Bioproduction and Bioproducts Industrial Biotechnology Diagnostics (incl. Biosensors) Industrial Microbiology (incl. Biofeedstocks) Industrial Molecular Engineering of Nucleic Acids and Proteins Industrial Biotechnology not elsewhere classified Medical Biotechnology Diagnostics (incl. Biosensors) Medical Molecular Engineering of Nucleic Acids and Proteins Regenerative Medicine (incl. Stem Cells and Tissue Engineering) Medical Biotechnology not elsewhere classified diacerein iron oxide microparticles osteoarthritis intra-articular injection rat model factorial design |
| dc.title.none.fl_str_mv | Image1_Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection.JPEG |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | Introduction<p>Osteoarthritis (OA) is regarded as one of the most prevealent irreversible joint degenerative disorder worldwide. Recently, considerable interest in utilizing intra-articular (IA) injections for managing OA has been raised.</p>Methods<p>In this study, IA injectable surface modified iron oxide microparticles (SMIOMPs) loaded with Diacerein (DCN) were developed. The effects of formulation parameters on particle size, entrapment efficiency, and zeta potential were explored using factorial design. The optimized formulation was characterized regarding morphology and in vitro release. Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR) were done to assess interactions. Further, sterilization and in vivo performance in rats with induced arthritis has been performed for the optimized formulation.</p>Results and Discussion<p>The selected optimized system included 2M FeCL3 and 1% chitosan as a surface modifier achieved high drug entrapment of 85.25% with a PS of 1.54 µm and sustained DCN release. Morphological examination of the optimized formulation revealed spherical particles with chitosan coat. DSC and FTIR results indicated the absence of undesired interactions between DCN and the used components. No significant change in the measured parameters was observed following sterilization using gamma radiation. In vivo assessment revealed superior performance for the optimized formulation in reducing cartilage inflammation and degradation. Plasma levels of tumor necrosis factor α and Interleukin-1 beta, as well as knee diameter, were significantly reduced in the treated groups compared to the untreated ones.</p>Conclusion<p>Overall, the results suggest that the proposed DCN-loaded SMIOMPs represent a promising advancement in the arena of cartilage regeneration.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_bfb686c537402df433d5cc12e0f87fbf |
| identifier_str_mv | 10.3389/fbioe.2024.1439085.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/27313905 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Image1_Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection.JPEGNouran Abdelmageed Ali (19956204)Nadia M. Morsi (4099249)Shaimaa M. Badr-Eldin (12134042)Rehab N. Shamma (4862437)BiotechnologyBiological EngineeringGenetic EngineeringBiomarkersBiomaterialsBiomechanical EngineeringBiomedical Engineering not elsewhere classifiedSynthetic BiologyAgricultural Marine BiotechnologyBioremediationBioprocessing, Bioproduction and BioproductsIndustrial Biotechnology Diagnostics (incl. Biosensors)Industrial Microbiology (incl. Biofeedstocks)Industrial Molecular Engineering of Nucleic Acids and ProteinsIndustrial Biotechnology not elsewhere classifiedMedical Biotechnology Diagnostics (incl. Biosensors)Medical Molecular Engineering of Nucleic Acids and ProteinsRegenerative Medicine (incl. Stem Cells and Tissue Engineering)Medical Biotechnology not elsewhere classifieddiacereiniron oxide microparticlesosteoarthritisintra-articular injectionrat modelfactorial designIntroduction<p>Osteoarthritis (OA) is regarded as one of the most prevealent irreversible joint degenerative disorder worldwide. Recently, considerable interest in utilizing intra-articular (IA) injections for managing OA has been raised.</p>Methods<p>In this study, IA injectable surface modified iron oxide microparticles (SMIOMPs) loaded with Diacerein (DCN) were developed. The effects of formulation parameters on particle size, entrapment efficiency, and zeta potential were explored using factorial design. The optimized formulation was characterized regarding morphology and in vitro release. Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR) were done to assess interactions. Further, sterilization and in vivo performance in rats with induced arthritis has been performed for the optimized formulation.</p>Results and Discussion<p>The selected optimized system included 2M FeCL3 and 1% chitosan as a surface modifier achieved high drug entrapment of 85.25% with a PS of 1.54 µm and sustained DCN release. Morphological examination of the optimized formulation revealed spherical particles with chitosan coat. DSC and FTIR results indicated the absence of undesired interactions between DCN and the used components. No significant change in the measured parameters was observed following sterilization using gamma radiation. In vivo assessment revealed superior performance for the optimized formulation in reducing cartilage inflammation and degradation. Plasma levels of tumor necrosis factor α and Interleukin-1 beta, as well as knee diameter, were significantly reduced in the treated groups compared to the untreated ones.</p>Conclusion<p>Overall, the results suggest that the proposed DCN-loaded SMIOMPs represent a promising advancement in the arena of cartilage regeneration.</p>2024-10-28T04:15:53ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.3389/fbioe.2024.1439085.s001https://figshare.com/articles/figure/Image1_Diacerein-loaded_surface_modified_iron_oxide_microparticles_SMIOMPs_an_emerging_magnetic_system_for_management_of_osteoarthritis_via_intra-articular_injection_JPEG/27313905CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/273139052024-10-28T04:15:53Z |
| spellingShingle | Image1_Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection.JPEG Nouran Abdelmageed Ali (19956204) Biotechnology Biological Engineering Genetic Engineering Biomarkers Biomaterials Biomechanical Engineering Biomedical Engineering not elsewhere classified Synthetic Biology Agricultural Marine Biotechnology Bioremediation Bioprocessing, Bioproduction and Bioproducts Industrial Biotechnology Diagnostics (incl. Biosensors) Industrial Microbiology (incl. Biofeedstocks) Industrial Molecular Engineering of Nucleic Acids and Proteins Industrial Biotechnology not elsewhere classified Medical Biotechnology Diagnostics (incl. Biosensors) Medical Molecular Engineering of Nucleic Acids and Proteins Regenerative Medicine (incl. Stem Cells and Tissue Engineering) Medical Biotechnology not elsewhere classified diacerein iron oxide microparticles osteoarthritis intra-articular injection rat model factorial design |
| status_str | publishedVersion |
| title | Image1_Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection.JPEG |
| title_full | Image1_Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection.JPEG |
| title_fullStr | Image1_Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection.JPEG |
| title_full_unstemmed | Image1_Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection.JPEG |
| title_short | Image1_Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection.JPEG |
| title_sort | Image1_Diacerein-loaded surface modified iron oxide microparticles (SMIOMPs): an emerging magnetic system for management of osteoarthritis via intra-articular injection.JPEG |
| topic | Biotechnology Biological Engineering Genetic Engineering Biomarkers Biomaterials Biomechanical Engineering Biomedical Engineering not elsewhere classified Synthetic Biology Agricultural Marine Biotechnology Bioremediation Bioprocessing, Bioproduction and Bioproducts Industrial Biotechnology Diagnostics (incl. Biosensors) Industrial Microbiology (incl. Biofeedstocks) Industrial Molecular Engineering of Nucleic Acids and Proteins Industrial Biotechnology not elsewhere classified Medical Biotechnology Diagnostics (incl. Biosensors) Medical Molecular Engineering of Nucleic Acids and Proteins Regenerative Medicine (incl. Stem Cells and Tissue Engineering) Medical Biotechnology not elsewhere classified diacerein iron oxide microparticles osteoarthritis intra-articular injection rat model factorial design |