Raw data used for generating figures.
<div><p>Hydrated electrons (e<sub>aq</sub><sup>-</sup>) are widely studied in pollutant degradation owing to their high reducing power. Recent studies indicate that transiently generated e<sub>aq</sub><sup>-</sup> during radiotherapy can en...
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2025
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| _version_ | 1849927643726610432 |
|---|---|
| author | Zhuangbin Zheng (22676304) |
| author2 | Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470) |
| author2_role | author author author author author author |
| author_facet | Zhuangbin Zheng (22676304) Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470) |
| author_role | author |
| dc.creator.none.fl_str_mv | Zhuangbin Zheng (22676304) Fanlei Ran (7352957) Lushan Liang (22676307) Yiqian Zhang (752795) Xianwen Li (3910537) Liqun Zhang (115900) Lijun Bi (121470) |
| dc.date.none.fl_str_mv | 2025-11-24T18:22:34Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0336479.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Raw_data_used_for_generating_figures_/30696435 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration |
| dc.title.none.fl_str_mv | Raw data used for generating figures. |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <div><p>Hydrated electrons (e<sub>aq</sub><sup>-</sup>) are widely studied in pollutant degradation owing to their high reducing power. Recent studies indicate that transiently generated e<sub>aq</sub><sup>-</sup> during radiotherapy can enhance chemotherapeutic antitumor effects via reduction activity. However, biomedical applications remain limited because conventional methods generate e<sub>aq</sub><sup>-</sup> in situ and are short-lived, precluding storage. In this study, we present a storable electromagnetic base liquid (EBL), reference-linked to prior preparation work, and analyze its physicochemical and organism-level effects. The EBL showed strong alkalinity (pH 13.08), low oxidation-reduction potential (ORP 47.1 mV), and a total antioxidant capacity of 1.6 mM Trolox equivalents antioxidant capacity. Using a larva zebrafish (<i>Danio rerio</i>) digital phenotyping platform, we identified a non-adverse concentration and generated unbiased predictions clustering EBL with antitumor, uric acid-lowering, and hypoglycemic drugs. These findings motivate further biological investigation of EBL’s biomedical potential and provide a basis for subsequent validation.</p></div> |
| eu_rights_str_mv | openAccess |
| id | Manara_c064d842298d0a968d89c52c98a91d9b |
| identifier_str_mv | 10.1371/journal.pone.0336479.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30696435 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Raw data used for generating figures.Zhuangbin Zheng (22676304)Fanlei Ran (7352957)Lushan Liang (22676307)Yiqian Zhang (752795)Xianwen Li (3910537)Liqun Zhang (115900)Lijun Bi (121470)PharmacologyBiotechnologyEvolutionary BiologyImmunologyInfectious DiseasesBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedtotal antioxidant capacityrecent studies indicateprior preparation workpollutant degradation owinglarva zebrafish (<high reducing powerdanio rerio </ebl ), referencetransiently generated ediv >< p1 mv ),biomedical effects studylevel effectsebl ’biomedical potentialbiomedical applicationwidely studieduric acidreduction potentialprecluding storageph 13orp 47new potentialshypoglycemic drugshydrated electronsfindings motivatebiological investigationadverse concentration<div><p>Hydrated electrons (e<sub>aq</sub><sup>-</sup>) are widely studied in pollutant degradation owing to their high reducing power. Recent studies indicate that transiently generated e<sub>aq</sub><sup>-</sup> during radiotherapy can enhance chemotherapeutic antitumor effects via reduction activity. However, biomedical applications remain limited because conventional methods generate e<sub>aq</sub><sup>-</sup> in situ and are short-lived, precluding storage. In this study, we present a storable electromagnetic base liquid (EBL), reference-linked to prior preparation work, and analyze its physicochemical and organism-level effects. The EBL showed strong alkalinity (pH 13.08), low oxidation-reduction potential (ORP 47.1 mV), and a total antioxidant capacity of 1.6 mM Trolox equivalents antioxidant capacity. Using a larva zebrafish (<i>Danio rerio</i>) digital phenotyping platform, we identified a non-adverse concentration and generated unbiased predictions clustering EBL with antitumor, uric acid-lowering, and hypoglycemic drugs. These findings motivate further biological investigation of EBL’s biomedical potential and provide a basis for subsequent validation.</p></div>2025-11-24T18:22:34ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.1371/journal.pone.0336479.s001https://figshare.com/articles/dataset/Raw_data_used_for_generating_figures_/30696435CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306964352025-11-24T18:22:34Z |
| spellingShingle | Raw data used for generating figures. Zhuangbin Zheng (22676304) Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration |
| status_str | publishedVersion |
| title | Raw data used for generating figures. |
| title_full | Raw data used for generating figures. |
| title_fullStr | Raw data used for generating figures. |
| title_full_unstemmed | Raw data used for generating figures. |
| title_short | Raw data used for generating figures. |
| title_sort | Raw data used for generating figures. |
| topic | Pharmacology Biotechnology Evolutionary Biology Immunology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified total antioxidant capacity recent studies indicate prior preparation work pollutant degradation owing larva zebrafish (< high reducing power danio rerio </ ebl ), reference transiently generated e div >< p 1 mv ), biomedical effects study level effects ebl ’ biomedical potential biomedical application widely studied uric acid reduction potential precluding storage ph 13 orp 47 new potentials hypoglycemic drugs hydrated electrons findings motivate biological investigation adverse concentration |