X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

<div><p>Chitinases are enzymes that catalyze the hydrolysis of chitin. Human chitotriosidase (CHIT1) is one of the two active human chitinases, involved in the innate immune response and highly expressed in a variety of diseases. CHIT1 is composed of a catalytic domain linked by a hinge...

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Bibliografiske detaljer
Hovedforfatter: Firas Fadel (2625211) (author)
Andre forfattere: Yuguang Zhao (229106) (author), Alexandra Cousido-Siah (777034) (author), Francesc X. Ruiz (777032) (author), André Mitschler (2625214) (author), Alberto Podjarny (777035) (author)
Udgivet: 2016
Fag:
Biophysics
Biochemistry
Cell Biology
Genetics
Molecular Biology
Biotechnology
Evolutionary Biology
Immunology
Developmental Biology
Cancer
Infectious Diseases
Plant Biology
Virology
Computational Biology
Chemical Sciences not elsewhere classified
house mite dust allergens
CBM 14 family members
Full Length Human Chitotriosidase
Human chitotriosidase
length CHIT 1
CBM 14 domain
CHIT 1
ChBD CHIT 1
CBM 14 family
crystallization approach
chitin binding domain
latter domain
Acidic Mammalian Chitinase
1.95 Å resolution
crystal structure
Chitin Binding Domain Chitinases
disulfide bridges
Trp 465
crystal structures
chitin binding
chitinase CHIT 1
cysteine residues
crystallization strategy
CHIT 1 chitin binding domain
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