Table8_Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.xlsx
<p>Backgrounds: Compared with previously published meta-analyses, this is the first study to investigate the combined effects of glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1 IIe105Val) and type 2 diabetes mellitus (T2DM) risk; moreover, the credibility of statistically signi...
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2025
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| _version_ | 1852014401786216448 |
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| author | Liang-shu Liu (14065578) |
| author2 | Di Wang (329735) Ru Tang (9927300) Qi Wang (22418) Lu Zheng (132726) Jian Wei (802495) Yan Li (23143) Xiao-feng He (11915585) |
| author2_role | author author author author author author author |
| author_facet | Liang-shu Liu (14065578) Di Wang (329735) Ru Tang (9927300) Qi Wang (22418) Lu Zheng (132726) Jian Wei (802495) Yan Li (23143) Xiao-feng He (11915585) |
| author_role | author |
| dc.creator.none.fl_str_mv | Liang-shu Liu (14065578) Di Wang (329735) Ru Tang (9927300) Qi Wang (22418) Lu Zheng (132726) Jian Wei (802495) Yan Li (23143) Xiao-feng He (11915585) |
| dc.date.none.fl_str_mv | 2025-12-01T03:11:49Z |
| dc.identifier.none.fl_str_mv | 10.3389/fgene.2022.959291.s008 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Table8_Individual_and_combined_effects_of_the_GSTM1_GSTT1_and_GSTP1_polymorphisms_on_type_2_diabetes_mellitus_risk_A_systematic_review_and_meta-analysis_xlsx/30748262 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy meta-analysis genetic polymorphism GSTM1 GSTP1 GSTT1 T2DM |
| dc.title.none.fl_str_mv | Table8_Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.xlsx |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p>Backgrounds: Compared with previously published meta-analyses, this is the first study to investigate the combined effects of glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1 IIe105Val) and type 2 diabetes mellitus (T2DM) risk; moreover, the credibility of statistically significant associations was assessed; furthermore, many new original studies were published.</p><p>Objectives: To determine the relationship between GSTM1, GSTT1, and GSTP1 polymorphisms with T2DM risk.</p><p>Methods: PubMed, Embase, Wanfang, and China National Knowledge Infrastructure Databases were searched. We quantify the relationship using crude odds ratios and their 95% confidence intervals Moreover, the Venice criteria, false-positive report probability (FPRP), and Bayesian false discovery probability (BFDP) were used to validate the significance of the results.</p><p>Results: Overall, significantly increased T2DM risk was found between individual and combined effects of GSTM1, GSTT1, and GSTP1 polymorphisms on T2DM risk, but, combined effects of the GSTT1 and GSTP1 polymorphisms was not statistically significant. GSTT1 gene polymorphism significantly increases the risk of T2DM complications, while GSTM1 and GSTP1 polymorphisms had no statistical significance. The GSTM1 null genotype was linked to a particularly increased risk of T2DM in Caucasians; the GSTT1 null genotype was connected to a significantly higher risk of T2DM in Asians and Indians; and the GSTP1 IIe105Val polymorphism was related to a substantially increased T2DM risk in Indians. Moreover, the GSTM1 and GSTT1 double null genotype was associated with substantially increased T2DM risk in Caucasians and Indians; the combined effects of GSTM1 and GSTP1 polymorphisms was associated with higher T2DM risk in Caucasians. However, all significant results were false when the Venice criteria, FPRP, and BFDP test were used (any FPRP >0.2 and BFDP value >0.8).</p><p>Conclusion: The current analysis strongly suggests that the individual and combined effects of GSTM1, GSTT1 and GSTP1 polymorphisms might not be connected with elevated T2DM risk.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_c19d52277378fade8642a1bb2e2e6da4 |
| identifier_str_mv | 10.3389/fgene.2022.959291.s008 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30748262 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Table8_Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.xlsxLiang-shu Liu (14065578)Di Wang (329735)Ru Tang (9927300)Qi Wang (22418)Lu Zheng (132726)Jian Wei (802495)Yan Li (23143)Xiao-feng He (11915585)GeneticsGenetic EngineeringBiomarkersDevelopmental Genetics (incl. Sex Determination)Epigenetics (incl. Genome Methylation and Epigenomics)Gene Expression (incl. Microarray and other genome-wide approaches)Genome Structure and RegulationGenomicsGenetically Modified AnimalsLivestock CloningGene and Molecular Therapymeta-analysisgenetic polymorphismGSTM1GSTP1GSTT1T2DM<p>Backgrounds: Compared with previously published meta-analyses, this is the first study to investigate the combined effects of glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1 IIe105Val) and type 2 diabetes mellitus (T2DM) risk; moreover, the credibility of statistically significant associations was assessed; furthermore, many new original studies were published.</p><p>Objectives: To determine the relationship between GSTM1, GSTT1, and GSTP1 polymorphisms with T2DM risk.</p><p>Methods: PubMed, Embase, Wanfang, and China National Knowledge Infrastructure Databases were searched. We quantify the relationship using crude odds ratios and their 95% confidence intervals Moreover, the Venice criteria, false-positive report probability (FPRP), and Bayesian false discovery probability (BFDP) were used to validate the significance of the results.</p><p>Results: Overall, significantly increased T2DM risk was found between individual and combined effects of GSTM1, GSTT1, and GSTP1 polymorphisms on T2DM risk, but, combined effects of the GSTT1 and GSTP1 polymorphisms was not statistically significant. GSTT1 gene polymorphism significantly increases the risk of T2DM complications, while GSTM1 and GSTP1 polymorphisms had no statistical significance. The GSTM1 null genotype was linked to a particularly increased risk of T2DM in Caucasians; the GSTT1 null genotype was connected to a significantly higher risk of T2DM in Asians and Indians; and the GSTP1 IIe105Val polymorphism was related to a substantially increased T2DM risk in Indians. Moreover, the GSTM1 and GSTT1 double null genotype was associated with substantially increased T2DM risk in Caucasians and Indians; the combined effects of GSTM1 and GSTP1 polymorphisms was associated with higher T2DM risk in Caucasians. However, all significant results were false when the Venice criteria, FPRP, and BFDP test were used (any FPRP >0.2 and BFDP value >0.8).</p><p>Conclusion: The current analysis strongly suggests that the individual and combined effects of GSTM1, GSTT1 and GSTP1 polymorphisms might not be connected with elevated T2DM risk.</p>2025-12-01T03:11:49ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fgene.2022.959291.s008https://figshare.com/articles/dataset/Table8_Individual_and_combined_effects_of_the_GSTM1_GSTT1_and_GSTP1_polymorphisms_on_type_2_diabetes_mellitus_risk_A_systematic_review_and_meta-analysis_xlsx/30748262CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307482622025-12-01T03:11:49Z |
| spellingShingle | Table8_Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.xlsx Liang-shu Liu (14065578) Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy meta-analysis genetic polymorphism GSTM1 GSTP1 GSTT1 T2DM |
| status_str | publishedVersion |
| title | Table8_Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.xlsx |
| title_full | Table8_Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.xlsx |
| title_fullStr | Table8_Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.xlsx |
| title_full_unstemmed | Table8_Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.xlsx |
| title_short | Table8_Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.xlsx |
| title_sort | Table8_Individual and combined effects of the GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus risk: A systematic review and meta-analysis.xlsx |
| topic | Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy meta-analysis genetic polymorphism GSTM1 GSTP1 GSTT1 T2DM |