Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials.tif
<p>Endometriosis is a chronic inflammatory disease characterized by pelvic pain and infertility, with oxidative stress playing a key role in its pathogenesis. Although antioxidant supplementation has been proposed as a potential adjunctive therapy in endometriosis, current evidence regarding i...
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2025
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| _version_ | 1851481641000632320 |
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| author | Yuchan Zhong (22518395) |
| author2 | Xinyu Qiao (12012113) Xin Huang (11077) Yujing Li (216269) Ruiying Wang (1995436) Jiagui Liang (22518398) Tingting Liu (267387) Wenjie Bo (22518401) Huiqiao Lai (22518404) Wei Huang (36889) |
| author2_role | author author author author author author author author author |
| author_facet | Yuchan Zhong (22518395) Xinyu Qiao (12012113) Xin Huang (11077) Yujing Li (216269) Ruiying Wang (1995436) Jiagui Liang (22518398) Tingting Liu (267387) Wenjie Bo (22518401) Huiqiao Lai (22518404) Wei Huang (36889) |
| author_role | author |
| dc.creator.none.fl_str_mv | Yuchan Zhong (22518395) Xinyu Qiao (12012113) Xin Huang (11077) Yujing Li (216269) Ruiying Wang (1995436) Jiagui Liang (22518398) Tingting Liu (267387) Wenjie Bo (22518401) Huiqiao Lai (22518404) Wei Huang (36889) |
| dc.date.none.fl_str_mv | 2025-10-29T06:30:16Z |
| dc.identifier.none.fl_str_mv | 10.3389/fmed.2025.1694281.s004 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Image_3_The_effects_of_antioxidant_supplementation_on_pain_oxidative_stress_markers_and_clinical_pregnancy_rate_in_women_with_endometriosis_a_systematic_review_and_meta-analysis_of_randomized_controlled_trials_tif/30476387 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Foetal Development and Medicine endometriosis antioxidant pelvic pain dysmenorrhea malondialdehyde clinical pregnancy rate |
| dc.title.none.fl_str_mv | Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials.tif |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Endometriosis is a chronic inflammatory disease characterized by pelvic pain and infertility, with oxidative stress playing a key role in its pathogenesis. Although antioxidant supplementation has been proposed as a potential adjunctive therapy in endometriosis, current evidence regarding its efficacy in symptom relief and fertility improvement remains inconclusive. This systematic review and meta-analysis included 21 randomized controlled trials involving 1,626 participants and evaluated more than 10 types of antioxidant supplementation, including vitamins, pentoxifylline, melatonin, astaxanthin, fish oil, and silymarin. The results showed that antioxidant supplementation significantly alleviated pelvic pain (continuous outcomes: SMD = −2.68; p < 0.00001; binary outcomes: RR = 9.31; p < 0.0001), dysmenorrhea (SMD = −1.77; p = 0.01; RR = 2.39; p = 0.03), and dyspareunia (SMD = −2.33; p = 0.01; RR = 5.40; p = 0.003), and significantly decreased peripheral blood malondialdehyde (MDA) levels (SMD = −7.58; p = 0.001). However, no significant effects were observed on overall pain (SMD = −1.14; p = 0.51) or clinical pregnancy rate (RR = 1.12; p = 0.52). Subgroup analyses further indicated that treatment efficacy varied by antioxidant type, disease stage, and duration of intervention. These findings suggest that antioxidant supplementation may offer therapeutic benefits in alleviating specific pain symptoms and reducing oxidative stress in women with endometriosis. Further large-scale and high-quality randomized controlled trials are needed to validate these results and establish optimal antioxidant strategies for long-term management of endometriosis.</p>Systematic review registration<p>PROSPERO CRD420251071723, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420251071723.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_c1fda81f6ebb593fcee8e03b15fdb623 |
| identifier_str_mv | 10.3389/fmed.2025.1694281.s004 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30476387 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials.tifYuchan Zhong (22518395)Xinyu Qiao (12012113)Xin Huang (11077)Yujing Li (216269)Ruiying Wang (1995436)Jiagui Liang (22518398)Tingting Liu (267387)Wenjie Bo (22518401)Huiqiao Lai (22518404)Wei Huang (36889)Foetal Development and Medicineendometriosisantioxidantpelvic paindysmenorrheamalondialdehydeclinical pregnancy rate<p>Endometriosis is a chronic inflammatory disease characterized by pelvic pain and infertility, with oxidative stress playing a key role in its pathogenesis. Although antioxidant supplementation has been proposed as a potential adjunctive therapy in endometriosis, current evidence regarding its efficacy in symptom relief and fertility improvement remains inconclusive. This systematic review and meta-analysis included 21 randomized controlled trials involving 1,626 participants and evaluated more than 10 types of antioxidant supplementation, including vitamins, pentoxifylline, melatonin, astaxanthin, fish oil, and silymarin. The results showed that antioxidant supplementation significantly alleviated pelvic pain (continuous outcomes: SMD = −2.68; p < 0.00001; binary outcomes: RR = 9.31; p < 0.0001), dysmenorrhea (SMD = −1.77; p = 0.01; RR = 2.39; p = 0.03), and dyspareunia (SMD = −2.33; p = 0.01; RR = 5.40; p = 0.003), and significantly decreased peripheral blood malondialdehyde (MDA) levels (SMD = −7.58; p = 0.001). However, no significant effects were observed on overall pain (SMD = −1.14; p = 0.51) or clinical pregnancy rate (RR = 1.12; p = 0.52). Subgroup analyses further indicated that treatment efficacy varied by antioxidant type, disease stage, and duration of intervention. These findings suggest that antioxidant supplementation may offer therapeutic benefits in alleviating specific pain symptoms and reducing oxidative stress in women with endometriosis. Further large-scale and high-quality randomized controlled trials are needed to validate these results and establish optimal antioxidant strategies for long-term management of endometriosis.</p>Systematic review registration<p>PROSPERO CRD420251071723, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420251071723.</p>2025-10-29T06:30:16ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.3389/fmed.2025.1694281.s004https://figshare.com/articles/figure/Image_3_The_effects_of_antioxidant_supplementation_on_pain_oxidative_stress_markers_and_clinical_pregnancy_rate_in_women_with_endometriosis_a_systematic_review_and_meta-analysis_of_randomized_controlled_trials_tif/30476387CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/304763872025-10-29T06:30:16Z |
| spellingShingle | Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials.tif Yuchan Zhong (22518395) Foetal Development and Medicine endometriosis antioxidant pelvic pain dysmenorrhea malondialdehyde clinical pregnancy rate |
| status_str | publishedVersion |
| title | Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials.tif |
| title_full | Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials.tif |
| title_fullStr | Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials.tif |
| title_full_unstemmed | Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials.tif |
| title_short | Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials.tif |
| title_sort | Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials.tif |
| topic | Foetal Development and Medicine endometriosis antioxidant pelvic pain dysmenorrhea malondialdehyde clinical pregnancy rate |