Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays.
<p>A-C. Dose response simulations for an example drug (trametinib). Median (across simulation replicates) cell population dynamics for several doses (A) and cell population lineage dendrograms for specific doses: 0 uM (B) and 0.1 uM (C) are shown. D-G. Simulated dose responses measured in GR-v...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2025
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| الموضوعات: | |
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| _version_ | 1852017156389076992 |
|---|---|
| author | Arnab Mutsuddy (22146227) |
| author2 | Jonah R. Huggins (13235400) Aurore K. Amrit (22146230) Atalanta Manuela Harley-Gasaway (22146233) Cemal Erdem (11054081) Evan T. Jones (22146236) Olivia G. Laurine (22146239) Jon C. Calhoun (22146242) Marc R. Birtwistle (10825523) |
| author2_role | author author author author author author author author |
| author_facet | Arnab Mutsuddy (22146227) Jonah R. Huggins (13235400) Aurore K. Amrit (22146230) Atalanta Manuela Harley-Gasaway (22146233) Cemal Erdem (11054081) Evan T. Jones (22146236) Olivia G. Laurine (22146239) Jon C. Calhoun (22146242) Marc R. Birtwistle (10825523) |
| author_role | author |
| dc.creator.none.fl_str_mv | Arnab Mutsuddy (22146227) Jonah R. Huggins (13235400) Aurore K. Amrit (22146230) Atalanta Manuela Harley-Gasaway (22146233) Cemal Erdem (11054081) Evan T. Jones (22146236) Olivia G. Laurine (22146239) Jon C. Calhoun (22146242) Marc R. Birtwistle (10825523) |
| dc.date.none.fl_str_mv | 2025-08-29T17:59:22Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pcbi.1013156.g002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Lineage_Resolved_Simulations_for_Comparing_Simulated_and_Experimental_Cell_Viability_Assays_/30014444 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biophysics Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified tracks simulated division strong growth inhibition slowly dividing cells mother cells prior measure cumulative division four targeted anti erk pathway activity better understanding determinants receptor inhibitor response egfr inhibitor ). 3k inhibitor ), mechanistic computational models xlink "> data cell viability assays cell cycle may simulations show subpopulations rapidly dividing phenotype drug treatment impinging data inconsistencies suggest previously developed model mek inhibitor suggest causes mechanistic modeling experimental data data comparison cell proliferation cell lineages 6 inhibitor work lays widely available treated conditions silico </ overall lack often muddled mammalian single lineage tracing induced signaling direct model detailed single death signaling death events critical determinant cellular heterogeneity cellular balance cancer drugs |
| dc.title.none.fl_str_mv | Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>A-C. Dose response simulations for an example drug (trametinib). Median (across simulation replicates) cell population dynamics for several doses (A) and cell population lineage dendrograms for specific doses: 0 uM (B) and 0.1 uM (C) are shown. D-G. Simulated dose responses measured in GR-value for four drugs compared experimental data. Error bars are standard error taken from original experimental data, or as calculated across simulation replicates (n=10).</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_c2cab8f7d530d183e227baefd43dbf86 |
| identifier_str_mv | 10.1371/journal.pcbi.1013156.g002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30014444 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays.Arnab Mutsuddy (22146227)Jonah R. Huggins (13235400)Aurore K. Amrit (22146230)Atalanta Manuela Harley-Gasaway (22146233)Cemal Erdem (11054081)Evan T. Jones (22146236)Olivia G. Laurine (22146239)Jon C. Calhoun (22146242)Marc R. Birtwistle (10825523)BiophysicsCell BiologyGeneticsMolecular BiologyPharmacologyBiotechnologyCancerHematologyBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedInformation Systems not elsewhere classifiedtracks simulated divisionstrong growth inhibitionslowly dividing cellsmother cells priormeasure cumulative divisionfour targeted antierk pathway activitybetter understanding determinantsreceptor inhibitor responseegfr inhibitor ).3k inhibitor ),mechanistic computational modelsxlink "> datacell viability assayscell cycle maysimulations show subpopulationsrapidly dividing phenotypedrug treatment impingingdata inconsistencies suggestpreviously developed modelmek inhibitorsuggest causesmechanistic modelingexperimental datadata comparisoncell proliferationcell lineages6 inhibitorwork layswidely availabletreated conditionssilico </overall lackoften muddledmammalian singlelineage tracinginduced signalingdirect modeldetailed singledeath signalingdeath eventscritical determinantcellular heterogeneitycellular balancecancer drugs<p>A-C. Dose response simulations for an example drug (trametinib). Median (across simulation replicates) cell population dynamics for several doses (A) and cell population lineage dendrograms for specific doses: 0 uM (B) and 0.1 uM (C) are shown. D-G. Simulated dose responses measured in GR-value for four drugs compared experimental data. Error bars are standard error taken from original experimental data, or as calculated across simulation replicates (n=10).</p>2025-08-29T17:59:22ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pcbi.1013156.g002https://figshare.com/articles/figure/Lineage_Resolved_Simulations_for_Comparing_Simulated_and_Experimental_Cell_Viability_Assays_/30014444CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/300144442025-08-29T17:59:22Z |
| spellingShingle | Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays. Arnab Mutsuddy (22146227) Biophysics Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified tracks simulated division strong growth inhibition slowly dividing cells mother cells prior measure cumulative division four targeted anti erk pathway activity better understanding determinants receptor inhibitor response egfr inhibitor ). 3k inhibitor ), mechanistic computational models xlink "> data cell viability assays cell cycle may simulations show subpopulations rapidly dividing phenotype drug treatment impinging data inconsistencies suggest previously developed model mek inhibitor suggest causes mechanistic modeling experimental data data comparison cell proliferation cell lineages 6 inhibitor work lays widely available treated conditions silico </ overall lack often muddled mammalian single lineage tracing induced signaling direct model detailed single death signaling death events critical determinant cellular heterogeneity cellular balance cancer drugs |
| status_str | publishedVersion |
| title | Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays. |
| title_full | Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays. |
| title_fullStr | Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays. |
| title_full_unstemmed | Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays. |
| title_short | Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays. |
| title_sort | Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays. |
| topic | Biophysics Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified tracks simulated division strong growth inhibition slowly dividing cells mother cells prior measure cumulative division four targeted anti erk pathway activity better understanding determinants receptor inhibitor response egfr inhibitor ). 3k inhibitor ), mechanistic computational models xlink "> data cell viability assays cell cycle may simulations show subpopulations rapidly dividing phenotype drug treatment impinging data inconsistencies suggest previously developed model mek inhibitor suggest causes mechanistic modeling experimental data data comparison cell proliferation cell lineages 6 inhibitor work lays widely available treated conditions silico </ overall lack often muddled mammalian single lineage tracing induced signaling direct model detailed single death signaling death events critical determinant cellular heterogeneity cellular balance cancer drugs |