Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays.

Lineage Resolved Simulations for Comparing Simulated and Experimental Cell Viability Assays.

<p>A-C. Dose response simulations for an example drug (trametinib). Median (across simulation replicates) cell population dynamics for several doses (A) and cell population lineage dendrograms for specific doses: 0 uM (B) and 0.1 uM (C) are shown. D-G. Simulated dose responses measured in GR-v...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Arnab Mutsuddy (22146227) (author)
مؤلفون آخرون: Jonah R. Huggins (13235400) (author), Aurore K. Amrit (22146230) (author), Atalanta Manuela Harley-Gasaway (22146233) (author), Cemal Erdem (11054081) (author), Evan T. Jones (22146236) (author), Olivia G. Laurine (22146239) (author), Jon C. Calhoun (22146242) (author), Marc R. Birtwistle (10825523) (author)
منشور في: 2025
الموضوعات:
Biophysics
Cell Biology
Genetics
Molecular Biology
Pharmacology
Biotechnology
Cancer
Hematology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Information Systems not elsewhere classified
tracks simulated division
strong growth inhibition
slowly dividing cells
mother cells prior
measure cumulative division
four targeted anti
erk pathway activity
better understanding determinants
receptor inhibitor response
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3k inhibitor ),
mechanistic computational models
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cell viability assays
cell cycle may
simulations show subpopulations
rapidly dividing phenotype
drug treatment impinging
data inconsistencies suggest
previously developed model
mek inhibitor
suggest causes
mechanistic modeling
experimental data
data comparison
cell proliferation
cell lineages
6 inhibitor
work lays
widely available
treated conditions
silico </
overall lack
often muddled
mammalian single
lineage tracing
induced signaling
direct model
detailed single
death signaling
death events
critical determinant
cellular heterogeneity
cellular balance
cancer drugs
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