Table 1_Age-related macular degeneration associated with optic disc drusen.pdf
Objective<p>The aim of this study was to investigate the risk of age-related macular degeneration (AMD) in association with optic disc drusen (ODD).</p>Design<p>This was an observational, cross-sectional study.</p>Participants<p>Participants were consecutive patients wi...
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2025
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| Summary: | Objective<p>The aim of this study was to investigate the risk of age-related macular degeneration (AMD) in association with optic disc drusen (ODD).</p>Design<p>This was an observational, cross-sectional study.</p>Participants<p>Participants were consecutive patients with and without ODD from the neuro-ophthalmology clinic. Ten patients with concomitant ODD-AMD were sub-analyzed.</p>Methods<p>The two cohorts were identified from a prospectively recruited dataset between July 2022 and June 2024. Patients received formal diagnoses of ODD and AMD after ophthalmic and imaging assessment. A logistic regression model was utilized in calculating AMD risk to account for demographic differences.</p>Results<p>A total of 94 patients with ODD (median age: 44 [Q1: 20, Q3: 69], 64% women) and 100 patients without ODD (median age: 60 [Q1: 44, Q3: 69], 48% women) were identified. AMD was observed in 9.6% and 3% of the ODD and non-ODD cohorts, respectively. The risk of AMD was higher in the ODD group (OR = 3.93, 95% CI: 0.89–21.85, p = 0.084). Although the association was not statistically significant, a logistic regression model attributed that to the age difference between the two cohorts. Of the 10 patients with ODD-AMD, 70% had a family history of AMD. These patients were all Caucasians and had a median age of 75 years (range: 56–91); 70% were women. Only 30% were smokers. On optic disc imaging, 70% of eyes demonstrated moderate-to-severe ODD.</p>Conclusion<p>Patients with ODD might be at a higher risk of AMD compared to patients without ODD, and AMD screening might be warranted. A family history of AMD is often present, indicating shared genetic risk factors.</p> |
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