Instant Protection Nanospray Bandage Driven Anti-Scar Wound Healing
Rapid wound coverage and bioactive intervention remain critical yet unmet needs in acute and traumatic wound management. Here, an instant film-forming nanospray bandage (QSFNPs_FFS) incorporating quercetin-loaded silk fibroin nanoparticles (QSFNPs) is developed as a multifunctional wound care strate...
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2025
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| _version_ | 1849927621543985152 |
|---|---|
| author | Manikumar Kodieswaran (22688323) |
| author2 | Rajat Dadheech (22688326) Debajyoti Pal (22688329) Chevella Maheshwari (22688332) Rupam Khatua (22688335) Samit Kumar Nandi (2835638) Biman B. Mandal (2835641) |
| author2_role | author author author author author author |
| author_facet | Manikumar Kodieswaran (22688323) Rajat Dadheech (22688326) Debajyoti Pal (22688329) Chevella Maheshwari (22688332) Rupam Khatua (22688335) Samit Kumar Nandi (2835638) Biman B. Mandal (2835641) |
| author_role | author |
| dc.creator.none.fl_str_mv | Manikumar Kodieswaran (22688323) Rajat Dadheech (22688326) Debajyoti Pal (22688329) Chevella Maheshwari (22688332) Rupam Khatua (22688335) Samit Kumar Nandi (2835638) Biman B. Mandal (2835641) |
| dc.date.none.fl_str_mv | 2025-11-26T09:09:32Z |
| dc.identifier.none.fl_str_mv | 10.1021/acsami.5c15025.s002 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/media/Instant_Protection_Nanospray_Bandage_Driven_Anti-Scar_Wound_Healing/30719659 |
| dc.rights.none.fl_str_mv | CC BY-NC 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biophysics Medicine Cell Biology Molecular Biology Immunology Cancer Infectious Diseases Space Science spectrum antibacterial efficiency significant occlusive retention rapid protective barrier enabling sustained release clinically relevant excipients attenuating oxidative stress traumatic wound management free tissue regeneration forming nanospray bandage nanospray bandage wound surface ultraviolet b translational potential suppressing yes regenerative process rationally engineered rabbit full instant film including broad fibrotic signaling associated protein 304 nm |
| dc.title.none.fl_str_mv | Instant Protection Nanospray Bandage Driven Anti-Scar Wound Healing |
| dc.type.none.fl_str_mv | Dataset Media info:eu-repo/semantics/publishedVersion dataset |
| description | Rapid wound coverage and bioactive intervention remain critical yet unmet needs in acute and traumatic wound management. Here, an instant film-forming nanospray bandage (QSFNPs_FFS) incorporating quercetin-loaded silk fibroin nanoparticles (QSFNPs) is developed as a multifunctional wound care strategy offering immediate protection and regeneration. The nanospray bandage is rationally engineered with clinically relevant excipients to form a rapid protective barrier on the wound surface while enabling sustained release of quercetin from QSFNPs for scar-free tissue regeneration. The instant protective film offers multifunctional barrier activity, including broad-spectrum antibacterial efficiency, significant occlusive retention, and Ultraviolet B (UVB, 304 nm) protection. The formulation modulates wound immune dynamics by attenuating oxidative stress and regulating early inflammatory responses. The released quercetin further guides the regenerative process while suppressing yes-associated protein (YAP) and transforming growth factor beta 1 (TGFβ1), thereby regulating pro-fibrotic signaling. Treatment with nanospray bandage in rabbit full-thickness wound models exhibits accelerated antiscar healing, highlighting its translational potential for acute and traumatic wound management. |
| eu_rights_str_mv | openAccess |
| id | Manara_c3176fe7b76c9148fc4a0d3ea1dd8476 |
| identifier_str_mv | 10.1021/acsami.5c15025.s002 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30719659 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY-NC 4.0 |
| spelling | Instant Protection Nanospray Bandage Driven Anti-Scar Wound HealingManikumar Kodieswaran (22688323)Rajat Dadheech (22688326)Debajyoti Pal (22688329)Chevella Maheshwari (22688332)Rupam Khatua (22688335)Samit Kumar Nandi (2835638)Biman B. Mandal (2835641)BiophysicsMedicineCell BiologyMolecular BiologyImmunologyCancerInfectious DiseasesSpace Sciencespectrum antibacterial efficiencysignificant occlusive retentionrapid protective barrierenabling sustained releaseclinically relevant excipientsattenuating oxidative stresstraumatic wound managementfree tissue regenerationforming nanospray bandagenanospray bandagewound surfaceultraviolet btranslational potentialsuppressing yesregenerative processrationally engineeredrabbit fullinstant filmincluding broadfibrotic signalingassociated protein304 nmRapid wound coverage and bioactive intervention remain critical yet unmet needs in acute and traumatic wound management. Here, an instant film-forming nanospray bandage (QSFNPs_FFS) incorporating quercetin-loaded silk fibroin nanoparticles (QSFNPs) is developed as a multifunctional wound care strategy offering immediate protection and regeneration. The nanospray bandage is rationally engineered with clinically relevant excipients to form a rapid protective barrier on the wound surface while enabling sustained release of quercetin from QSFNPs for scar-free tissue regeneration. The instant protective film offers multifunctional barrier activity, including broad-spectrum antibacterial efficiency, significant occlusive retention, and Ultraviolet B (UVB, 304 nm) protection. The formulation modulates wound immune dynamics by attenuating oxidative stress and regulating early inflammatory responses. The released quercetin further guides the regenerative process while suppressing yes-associated protein (YAP) and transforming growth factor beta 1 (TGFβ1), thereby regulating pro-fibrotic signaling. Treatment with nanospray bandage in rabbit full-thickness wound models exhibits accelerated antiscar healing, highlighting its translational potential for acute and traumatic wound management.2025-11-26T09:09:32ZDatasetMediainfo:eu-repo/semantics/publishedVersiondataset10.1021/acsami.5c15025.s002https://figshare.com/articles/media/Instant_Protection_Nanospray_Bandage_Driven_Anti-Scar_Wound_Healing/30719659CC BY-NC 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307196592025-11-26T09:09:32Z |
| spellingShingle | Instant Protection Nanospray Bandage Driven Anti-Scar Wound Healing Manikumar Kodieswaran (22688323) Biophysics Medicine Cell Biology Molecular Biology Immunology Cancer Infectious Diseases Space Science spectrum antibacterial efficiency significant occlusive retention rapid protective barrier enabling sustained release clinically relevant excipients attenuating oxidative stress traumatic wound management free tissue regeneration forming nanospray bandage nanospray bandage wound surface ultraviolet b translational potential suppressing yes regenerative process rationally engineered rabbit full instant film including broad fibrotic signaling associated protein 304 nm |
| status_str | publishedVersion |
| title | Instant Protection Nanospray Bandage Driven Anti-Scar Wound Healing |
| title_full | Instant Protection Nanospray Bandage Driven Anti-Scar Wound Healing |
| title_fullStr | Instant Protection Nanospray Bandage Driven Anti-Scar Wound Healing |
| title_full_unstemmed | Instant Protection Nanospray Bandage Driven Anti-Scar Wound Healing |
| title_short | Instant Protection Nanospray Bandage Driven Anti-Scar Wound Healing |
| title_sort | Instant Protection Nanospray Bandage Driven Anti-Scar Wound Healing |
| topic | Biophysics Medicine Cell Biology Molecular Biology Immunology Cancer Infectious Diseases Space Science spectrum antibacterial efficiency significant occlusive retention rapid protective barrier enabling sustained release clinically relevant excipients attenuating oxidative stress traumatic wound management free tissue regeneration forming nanospray bandage nanospray bandage wound surface ultraviolet b translational potential suppressing yes regenerative process rationally engineered rabbit full instant film including broad fibrotic signaling associated protein 304 nm |