Removal of IKK in microglia induces changes in microglia number and morphology during prion infection.

Removal of IKK in microglia induces changes in microglia number and morphology during prion infection.

<p>Terminal mice with IKK KO microglia were compared to wpi-matched WT infected mice. <b>A</b> Brains were stained for Iba1 + microglia, which were counted and compared in the <b>B</b> cortex, <b>C</b> hippocampus, <b>D</b> thalamus and <b>...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autor: Arielle J. D. Hay (15456341) (author)
Další autoři: Katriana A. Popichak (12093647) (author), Genova Mumford (15456344) (author), Jifeng Bian (354060) (author), Payton Shirley (21568259) (author), Lauren Wolfrath (21568262) (author), Michael Eggers (21568265) (author), Eric M. Nicholson (8262054) (author), Ronald B. Tjalkens (3281031) (author), Mark D. Zabel (15456359) (author), Julie A. Moreno (7647266) (author)
Vydáno: 2025
Témata:
Medicine
Microbiology
Cell Biology
Genetics
Molecular Biology
Neuroscience
Physiology
Immunology
Cancer
Infectious Diseases
iκb kinase complex
cellular stress signals
irreversible neuronal loss
associated behavioral deficits
sc </ sup
prion disease pathogenesis
prion disease early
div >< p
cellular prion protein
inflammatory signaling molecules
infected brain homogenates
terminal wt mice
induced glial inflammation
accelerated disease
terminal animals
protein homeostasis
inflammatory cytokines
induced transcription
accelerated loss
prion diseases
signaling pathway
intracranially infected
infected wild
infected brain
b signaling
specific pathology
significantly lower
significantly increased
significantly downregulated
poorly understood
nuclear factor
near ablation
microglial survival
key regulator
kappa b
infectious form
increased density
including pro
host protection
hippocampal neurons
glial cells
forms aggregates
findings present
cell survival
associated genes
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Podobné jednotky

Podobné jednotky