Synaptic plasticity in spinal Calcrl<sup>+</sup> neurons under chronic itch condition.

Synaptic plasticity in spinal Calcrl<sup>+</sup> neurons under chronic itch condition.

<p><b>(A)</b> Summarized table of Aβ-evoked IPSCs, EPSCs, and APs in Sham and chronic itch mice. Statistical analysis: chi-square test. <b>(B)</b> Representative traces showing Aβ-evoked IPSCs of spinal Calcrl<sup>+</sup> neurons from Sham (black trace) and...

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Bibliografiske detaljer
Hovedforfatter:	Huifeng Jiao (11537806) (author)
Andre forfattere:	Qi Dai (196898) (author), Zhaoting Li (5491976) (author), Min Yuan (202757) (author), Guoqun Xu (22633999) (author), Yingxin Tian (489748) (author), Guangyuan Su (22634002) (author), Yu Zhang (12946) (author), Chong Sun (2134873) (author), Shunqi Wang (9677645) (author), Chaolin Ma (7547090) (author), Haili Pan (12404423) (author)
Udgivet:	2025
Fag:	Biophysics Medicine Cell Biology Neuroscience Physiology Biotechnology Developmental Biology Science Policy Infectious Diseases Biological Sciences not elsewhere classified sup >+</ sup spontaneous scratching behaviors providing actionable targets evoked synaptic excitation evoked excitatory transmission div >< p devastating dermatological disorder mechanical itch signaling mechanical itch sensitization mechanical itch pathophysiology reduced inhibitory input chronic itch models chronic itch model allergic contact dermatitis using chemogenetic manipulation neurons undergo hyperexcitability downstream urocortin 3 spinal projection neurons wherein spinal calcrl chronic itch spinal calcrl inhibitory interneurons atopic dermatitis chemogenetic inhibition chemogenetic activation expressing neurons significantly amplified seminal studies present study neural circuitry naïve mice morphological assays like receptor incomplete understanding findings establish electrophysiological approaches dependent circuit critical driver calcitonin receptor behavioral tests
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Summary:	<p><b>(A)</b> Summarized table of Aβ-evoked IPSCs, EPSCs, and APs in Sham and chronic itch mice. Statistical analysis: chi-square test. <b>(B)</b> Representative traces showing Aβ-evoked IPSCs of spinal Calcrl<sup>+</sup> neurons from Sham (black trace) and ACD (red trace) mice. <b>(C)</b> Quantification revealed significantly reduced IPSC responses in chronic itch mice. Group differences were statistically evaluated using a two-tailed unpaired Student’s t-test. <b>(D)</b> Representative traces for Aβ-induced EPSCs of spinal Calcrl<sup>+</sup> neurons from Sham (black) and ACD (red) mice. <b>(E)</b> Quantification revealed EPSC responses were significantly increased in chronic itch mice. Differences between the groups were analyzed by a two-tailed unpaired Student’s t-test. <b>(F)</b> Typical traces for Aβ-induced IPSP or AP of spinal Calcrl<sup>+</sup> neurons from Sham (black) and ACD (red) mice. Data are presented as mean ± SEM (n = 5 mice per group). p < 0.01, *p < 0.001. Red arrowheads denote stimulation artifacts.</p>