Synaptic plasticity in spinal Calcrl<sup>+</sup> neurons under chronic itch condition.

Synaptic plasticity in spinal Calcrl<sup>+</sup> neurons under chronic itch condition.

<p><b>(A)</b> Summarized table of Aβ-evoked IPSCs, EPSCs, and APs in Sham and chronic itch mice. Statistical analysis: chi-square test. <b>(B)</b> Representative traces showing Aβ-evoked IPSCs of spinal Calcrl<sup>+</sup> neurons from Sham (black trace) and...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Huifeng Jiao (11537806) (author)
مؤلفون آخرون:	Qi Dai (196898) (author), Zhaoting Li (5491976) (author), Min Yuan (202757) (author), Guoqun Xu (22633999) (author), Yingxin Tian (489748) (author), Guangyuan Su (22634002) (author), Yu Zhang (12946) (author), Chong Sun (2134873) (author), Shunqi Wang (9677645) (author), Chaolin Ma (7547090) (author), Haili Pan (12404423) (author)
منشور في:	2025
الموضوعات:	Biophysics Medicine Cell Biology Neuroscience Physiology Biotechnology Developmental Biology Science Policy Infectious Diseases Biological Sciences not elsewhere classified sup >+</ sup spontaneous scratching behaviors providing actionable targets evoked synaptic excitation evoked excitatory transmission div >< p devastating dermatological disorder mechanical itch signaling mechanical itch sensitization mechanical itch pathophysiology reduced inhibitory input chronic itch models chronic itch model allergic contact dermatitis using chemogenetic manipulation neurons undergo hyperexcitability downstream urocortin 3 spinal projection neurons wherein spinal calcrl chronic itch spinal calcrl inhibitory interneurons atopic dermatitis chemogenetic inhibition chemogenetic activation expressing neurons significantly amplified seminal studies present study neural circuitry naïve mice morphological assays like receptor incomplete understanding findings establish electrophysiological approaches dependent circuit critical driver calcitonin receptor behavioral tests
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مواد مشابهة

Chemogenetic inhibition of Calcrl<sup>+</sup> neurons attenuates chronic itch in multiple chronic itch models.
حسب: Huifeng Jiao (11537806)
منشور في: (2025)

Enhanced intrinsic excitability of spinal Calcrl<sup>+</sup> neurons in chronic itch.
حسب: Huifeng Jiao (11537806)
منشور في: (2025)

Chemogenetic modulation of spinal Calcrl<sup>+</sup> neurons alters mechanical itch responses.
حسب: Huifeng Jiao (11537806)
منشور في: (2025)

Schematic showing neural circuits in spinal dorsal horn mediating sensory modalities.
حسب: Huifeng Jiao (11537806)
منشور في: (2025)

<b>Optimal Itch Response in Adults Treated with Dupilumab for Moderate-to-Severe Atopic Dermatitis</b>
حسب: Adis journals on behalf of: (21516103)
منشور في: (2025)

Presentation 1_Oncostatin M enhances the lengthening of sensory nerves and skin hypersensitivity.pptx
حسب: Chie Ishikawa (84845)
منشور في: (2025)

Early itch relief with ivarmacitinib improves quality of life, working productivity, and sleep quality in patients with moderate-to-severe atopic dermatitis: a post hoc analysis of a phase III trial
حسب: Chengyao Zhu (22228915)
منشور في: (2025)

Expression profiles of itch mediators during scabies infection.
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

Immunohistological localisation of itch mediators in porcine skin biopsies.
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

α2δ2 and α2δ4, but not α2δ3, contribute to itch processing.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

Data Sheet 1_Tmem45b modulates itch via endoplasmic reticulum calcium regulation.docx
حسب: Sa-shuang Wang (22817120)
منشور في: (2025)

Table 1_Efficacy and safety of oral ivermectin versus benzyl benzoate for the treatment of scabies: a systematic review and meta-analysis of randomized controlled trials.docx
حسب: Ahmed Abu-Zaid (8896541)
منشور في: (2025)

Modulation of the α2δ expression levels by tissue or nerve injury. The expression levels of each VGCC auxiliary α2δ subtype was quantified using <i>in situ</i> hybridization in naïve (WT) mice and 7 days (SNI) or 3 days (CFA) after nerve (SNI) or tissue (CFA) injury, respectively. Values represent mean intensity fluorescence (N = 3; levels within each tissue were compared between WT and SNI or CFA using Student’s t-test * p < 0.05; ** p < 0.01, *** p < 0.005).
حسب: Joao M. Braz (12126570)
منشور في: (2025)

Anatomical changes in α2δ2 subunit mutant mice.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

VGCC auxiliary α2δ subtypes do not contribute to chronic pain.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

<i>Cacna2d4</i> KO mice exhibit hyposensitivity across multiple modalities.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

<i>Cacna2d3</i> expressed in sensory neurons contributes to the thermal deficits in <i>Cacna2d3</i> KO mice.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

Male and female <i>Cacna2d3</i> KO mice exhibit hyposensitivity to thermal stimuli.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

<i>Cacna2d2</i> heterozygous male, but not female mice, exhibit hypersensitivity across modalities.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

DRG expression pattern of VGCC subtypes.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

DRG expression of VGCCs is modulated by peripheral nerve injury.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

Minimal Data Set.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

Spinal cord expression of VGCCs.
حسب: Joao M. Braz (12126570)
منشور في: (2025)

Expression of Substance P (raw data).
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

Expression of NK-1R (raw data).
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

Expression of IL-31 (raw data).
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

Expression of Tryptase (raw data).
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

Expression of Histamine (raw data).
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

Expression of Periostin (raw data).
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

Expression of β tubulin III (raw data).
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

Expression of MRGX2 (raw data).
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

Expression of PAR2 (raw data).
حسب: Deepani D. Fernando (9450353)
منشور في: (2025)

Image 1_The role of LSR gene variants in early onset intrahepatic cholestasis: a case series with treatment options.png
حسب: Sinja Ohlsson (11770463)
منشور في: (2025)

Comparison of different radiotherapy fractionation schedule for grading radiodermatitis and symptoms associated with radiodermatitis.
حسب: Xiaomeng Lu (1553095)
منشور في: (2025)

Self-reported symptoms of radiation dermatitis in both groups.
حسب: Xiaomeng Lu (1553095)
منشور في: (2025)

Comparison the degree of radiodermatitis between the two groups.
حسب: Xiaomeng Lu (1553095)
منشور في: (2025)

Demographic and clinical characteristics of patients at baseline (n = 183).
حسب: Xiaomeng Lu (1553095)
منشور في: (2025)

KM curve for swelling with different radiotherapy fractionations.
حسب: Xiaomeng Lu (1553095)
منشور في: (2025)

KM curve for burning with different radiotherapy fractionations.
حسب: Xiaomeng Lu (1553095)
منشور في: (2025)

KM curve for tightness with different radiotherapy fractionations.
حسب: Xiaomeng Lu (1553095)
منشور في: (2025)