Known rosette-mediating PfEMP1 variants and associated domain cassettes.

<p>A) Diagram of the PfEMP1 domain architecture of known rosette-mediating variants [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref014" target="_blank">14</a>–<a href="http://www.plospathogens.org/art...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Florence E. McLean (20553214) (author)
مؤلفون آخرون:	Brian R. Omondi (10077082) (author), Nouhoum Diallo (3134631) (author), Stanley Otoboh (20553217) (author), Carolyne Kifude (170297) (author), Abdirahman I. Abdi (7477841) (author), Rivka Lim (9010286) (author), Thomas D. Otto (7847135) (author), Ashfaq Ghumra (170275) (author), J. Alexandra Rowe (16641657) (author)
منشور في:	2025
الموضوعات:	Microbiology Cell Biology Genetics Cancer Infectious Diseases Plant Biology Virology Computational Biology Physical Sciences not elsewhere classified variant surface antigens thirteen recent culture terminal domains known parasite immune evasion making functional sense genomic data relies pfemp1 sequences encoding mediating pfemp1 variants like pfemp1 binds high rosette frequency plasmodium falciparum </ predicted dc11 type infer binding phenotype associated rosetting phenotype pfemp1 type falciparum </ previously associated pfemp1 types pfemp1 repertoires rosette selection rosette disruption eight rosette vitro </ var </ p </ three dc11 rosetting mechanisms one showing mediates binding malaria pathology key role kenyan lines increased availability human cells form rosettes first analysed dual rosetting also showed
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الوصف
الملخص:	<p>A) Diagram of the PfEMP1 domain architecture of known rosette-mediating variants [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref014" target="_blank">14</a>–<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref017" target="_blank">17</a>]. The rosetting-associated head structure, DBLα1.5/6/8-CIDRβ/γ/δ, is boxed. Domains that bind erythrocytes (RBC) or serum proteins (IgM and alpha2Macroglobulin, α2M) are indicated. <b>B)</b> Diagram of domain cassettes (DCs) [as described by [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref027" target="_blank">27</a>]] which are relevant to the rosetting PfEMP1 variants characterised previously.</p>

Known rosette-mediating PfEMP1 variants and associated domain cassettes.

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