Known rosette-mediating PfEMP1 variants and associated domain cassettes.
<p>A) Diagram of the PfEMP1 domain architecture of known rosette-mediating variants [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref014" target="_blank">14</a>–<a href="http://www.plospathogens.org/art...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2025
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| _version_ | 1852023641068273664 |
|---|---|
| author | Florence E. McLean (20553214) |
| author2 | Brian R. Omondi (10077082) Nouhoum Diallo (3134631) Stanley Otoboh (20553217) Carolyne Kifude (170297) Abdirahman I. Abdi (7477841) Rivka Lim (9010286) Thomas D. Otto (7847135) Ashfaq Ghumra (170275) J. Alexandra Rowe (16641657) |
| author2_role | author author author author author author author author author |
| author_facet | Florence E. McLean (20553214) Brian R. Omondi (10077082) Nouhoum Diallo (3134631) Stanley Otoboh (20553217) Carolyne Kifude (170297) Abdirahman I. Abdi (7477841) Rivka Lim (9010286) Thomas D. Otto (7847135) Ashfaq Ghumra (170275) J. Alexandra Rowe (16641657) |
| author_role | author |
| dc.creator.none.fl_str_mv | Florence E. McLean (20553214) Brian R. Omondi (10077082) Nouhoum Diallo (3134631) Stanley Otoboh (20553217) Carolyne Kifude (170297) Abdirahman I. Abdi (7477841) Rivka Lim (9010286) Thomas D. Otto (7847135) Ashfaq Ghumra (170275) J. Alexandra Rowe (16641657) |
| dc.date.none.fl_str_mv | 2025-01-13T19:05:12Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.ppat.1012434.g001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Known_rosette-mediating_PfEMP1_variants_and_associated_domain_cassettes_/28198786 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Microbiology Cell Biology Genetics Cancer Infectious Diseases Plant Biology Virology Computational Biology Physical Sciences not elsewhere classified variant surface antigens thirteen recent culture terminal domains known parasite immune evasion making functional sense genomic data relies pfemp1 sequences encoding mediating pfemp1 variants like pfemp1 binds high rosette frequency plasmodium falciparum </ predicted dc11 type infer binding phenotype associated rosetting phenotype pfemp1 type falciparum </ previously associated pfemp1 types pfemp1 repertoires rosette selection rosette disruption eight rosette vitro </ var </ p </ three dc11 rosetting mechanisms one showing mediates binding malaria pathology key role kenyan lines increased availability human cells form rosettes first analysed dual rosetting also showed |
| dc.title.none.fl_str_mv | Known rosette-mediating PfEMP1 variants and associated domain cassettes. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>A) Diagram of the PfEMP1 domain architecture of known rosette-mediating variants [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref014" target="_blank">14</a>–<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref017" target="_blank">17</a>]. The rosetting-associated head structure, DBLα1.5/6/8-CIDRβ/γ/δ, is boxed. Domains that bind erythrocytes (RBC) or serum proteins (IgM and alpha2Macroglobulin, α2M) are indicated. <b>B)</b> Diagram of domain cassettes (DCs) [as described by [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref027" target="_blank">27</a>]] which are relevant to the rosetting PfEMP1 variants characterised previously.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_c4df4e27f67306cda55c9d720a8a8f17 |
| identifier_str_mv | 10.1371/journal.ppat.1012434.g001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/28198786 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Known rosette-mediating PfEMP1 variants and associated domain cassettes.Florence E. McLean (20553214)Brian R. Omondi (10077082)Nouhoum Diallo (3134631)Stanley Otoboh (20553217)Carolyne Kifude (170297)Abdirahman I. Abdi (7477841)Rivka Lim (9010286)Thomas D. Otto (7847135)Ashfaq Ghumra (170275)J. Alexandra Rowe (16641657)MicrobiologyCell BiologyGeneticsCancerInfectious DiseasesPlant BiologyVirologyComputational BiologyPhysical Sciences not elsewhere classifiedvariant surface antigensthirteen recent cultureterminal domains knownparasite immune evasionmaking functional sensegenomic data reliespfemp1 sequences encodingmediating pfemp1 variantslike pfemp1 bindshigh rosette frequencyplasmodium falciparum </predicted dc11 typeinfer binding phenotypeassociated rosetting phenotypepfemp1 typefalciparum </previously associatedpfemp1 typespfemp1 repertoiresrosette selectionrosette disruptioneight rosettevitro </var </p </three dc11rosetting mechanismsone showingmediates bindingmalaria pathologykey rolekenyan linesincreased availabilityhuman cellsform rosettesfirst analyseddual rosettingalso showed<p>A) Diagram of the PfEMP1 domain architecture of known rosette-mediating variants [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref014" target="_blank">14</a>–<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref017" target="_blank">17</a>]. The rosetting-associated head structure, DBLα1.5/6/8-CIDRβ/γ/δ, is boxed. Domains that bind erythrocytes (RBC) or serum proteins (IgM and alpha2Macroglobulin, α2M) are indicated. <b>B)</b> Diagram of domain cassettes (DCs) [as described by [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012434#ppat.1012434.ref027" target="_blank">27</a>]] which are relevant to the rosetting PfEMP1 variants characterised previously.</p>2025-01-13T19:05:12ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.ppat.1012434.g001https://figshare.com/articles/figure/Known_rosette-mediating_PfEMP1_variants_and_associated_domain_cassettes_/28198786CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/281987862025-01-13T19:05:12Z |
| spellingShingle | Known rosette-mediating PfEMP1 variants and associated domain cassettes. Florence E. McLean (20553214) Microbiology Cell Biology Genetics Cancer Infectious Diseases Plant Biology Virology Computational Biology Physical Sciences not elsewhere classified variant surface antigens thirteen recent culture terminal domains known parasite immune evasion making functional sense genomic data relies pfemp1 sequences encoding mediating pfemp1 variants like pfemp1 binds high rosette frequency plasmodium falciparum </ predicted dc11 type infer binding phenotype associated rosetting phenotype pfemp1 type falciparum </ previously associated pfemp1 types pfemp1 repertoires rosette selection rosette disruption eight rosette vitro </ var </ p </ three dc11 rosetting mechanisms one showing mediates binding malaria pathology key role kenyan lines increased availability human cells form rosettes first analysed dual rosetting also showed |
| status_str | publishedVersion |
| title | Known rosette-mediating PfEMP1 variants and associated domain cassettes. |
| title_full | Known rosette-mediating PfEMP1 variants and associated domain cassettes. |
| title_fullStr | Known rosette-mediating PfEMP1 variants and associated domain cassettes. |
| title_full_unstemmed | Known rosette-mediating PfEMP1 variants and associated domain cassettes. |
| title_short | Known rosette-mediating PfEMP1 variants and associated domain cassettes. |
| title_sort | Known rosette-mediating PfEMP1 variants and associated domain cassettes. |
| topic | Microbiology Cell Biology Genetics Cancer Infectious Diseases Plant Biology Virology Computational Biology Physical Sciences not elsewhere classified variant surface antigens thirteen recent culture terminal domains known parasite immune evasion making functional sense genomic data relies pfemp1 sequences encoding mediating pfemp1 variants like pfemp1 binds high rosette frequency plasmodium falciparum </ predicted dc11 type infer binding phenotype associated rosetting phenotype pfemp1 type falciparum </ previously associated pfemp1 types pfemp1 repertoires rosette selection rosette disruption eight rosette vitro </ var </ p </ three dc11 rosetting mechanisms one showing mediates binding malaria pathology key role kenyan lines increased availability human cells form rosettes first analysed dual rosetting also showed |